Besides the genetic/hereditary link...
And the environmental trigger or cumulative environmental triggers possibly/coupled with a genetic predisposition to damage from them...
There's a lot of research going on into a link between gastro-intestinal problems being linked with brain function and development, and that being a cause of it. Basically the GI tract houses the immune system, and has a huge impact on brain function, and there are thoughts that deficiencies in it or problems with yeast overgrowth or an inability to process certain proteins means certain nutrients aren't easily absorbed, and that this has an impact on the brain.
Similarly, there's thought that it could also be linked to the immune system and brain and GI tract as well.
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We are a fever, we are a fever, we ain't born typical...