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Livelock
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25 Apr 2013, 8:28 pm

I saw this article today that there was a Vaccine to prevent autism. More shocking there was the theory behind it that apparently Autism Gastrointestinal Bacteria had been linked to Autism a while back.
I searched the forum and have seen a couple topics on the subject over the years but really not much talk of it.

http://www.scienceworldreport.com/artic ... mptoms.htm

Quote:
The first ever vaccine for gut bacteria, common in autistic children, was designed by researchers from the University of Guelph. The ground-breaking study was conducted by Brittany Pequegnat and Guelph chemistry professor Mario Monteiro.

The new carbohydrate vaccine fights against bacteria present in the gut known as Clostridium bolteae, which plays a major role in gastrointestinal disorders. The number of C.bolteae is more in the gastrointestinal tracts of autistic kids when compared to those of healthy children.


Reports according to current literature state that more than 90 percent of kids with autism spectrum disorder suffer with severe chronic gastrointestinal symptoms. Out of this, 75 percent suffer from diarrhea.

"Little is known about the factors that predispose autistic children to C. bolteae," said Monteiro. "Although most infections are handled by some antibiotics, a vaccine would improve current treatment. This is the first vaccine designed to control constipation and diarrhea caused by C. bolteae and perhaps control autism-related symptoms associated with this microbe."

It was believed by many researchers that the toxins produced by gut bacteria, including C.boltea, are linked with symptoms and severity of autism, especially regressive autism.

To test this, the researchers worked on a bacteria grown in the lab. They noticed that the vaccine attacks particular complex polysaccharides or carbohydrates that are present on the surface of the bug. When tested on rabbits, the vaccine increased the C.bolteae antibodies.

According to Monteiro, it might take more than 10 years for the vaccine to work through preclinical and human trials, and even longer before a drug is ready to hit the market.


Here's a site that has a few studies listed on the subject.
http://crackingtheenigma.blogspot.com/2 ... nigma.html

What do you guys think?



DeaconBlues
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25 Apr 2013, 9:48 pm

I think the "experts" cited here are full of bovine byproduct.


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AgentPalpatine
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25 Apr 2013, 10:00 pm

I've never heard of the university, it's apparently in Canada, but one would think we would have heard of it before.


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Nonperson
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25 Apr 2013, 10:04 pm

It looks like it's actually designed to control diarrhea and constipation, and the idea that it will also cure autism is just wishful thinking on their part.



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25 Apr 2013, 10:40 pm

More Snake Oil as always.


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Highlander852456
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25 Apr 2013, 11:52 pm

Probably only reduces the severity of certain forms of autism.



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26 Apr 2013, 12:14 am

AgentPalpatine wrote:
I've never heard of the university, it's apparently in Canada, but one would think we would have heard of it before.


It's not one of the bigger schools that are well known internationally, but I'd say it's reputable.

I've come across the theory before. Guelph University isn't the only institution with researchers looking into possible connections between autism and gut bacteria.

Personally, I won't automatically dismiss the possibility that some kinds of autism might be linked to things like gastrointentistinal problems (although the idea that gut bacteria alone cause autism is something I find hard to believe) -- the body is a complicated thing after all, and sometimes issues in one body system affect others.

If nothing else, kids on the spectrum with GI problems might find the GI problems go away.


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Janissy
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26 Apr 2013, 11:42 am

Another possibility (not discussed in this article) for altered gut flora is fecal transplant. There are some parents of autistics kids (not me) who have done this at home. I think it is unsafe and probably traumatizing to do this at home. However, hospitals are starting to do fecal transplants. Currently they only do it for Clostridium difficile overgrowth but the theory is the same. Rather than killing (with antibiotics) or vaccinating against (with this vaccine) a particular bacteria, you let the healthy mix of bacteria overgrow the problematic ones.

A vaccine assumes that you are correct about which bacteria is the problematic one. If you are wrong, the vaccination is worthless and possibly damaging if it turns out that human guts are meant to have C.boltae but in lesser amounts. The fecal transplant gets around that problem.

Since there has also been found to be an altered mix of gut flora in obese people, possibly making it much harder for them to lose weight (since your gut flora affects what happens to your food), there will probably be an increased demand for fecal transplants. Add in antibiotic resistance and fecal transplants are looking better and better.

Although my daughter is not one of the kids affected by gut issues, there seem to be many who are. Malnutrition, as well as gut pain, is a possible consequence of having the "wrong" gut flora. Even if altering the gut flora for the better has no effect on autism, there is potentially great positive effect for gut issues.



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29 Apr 2013, 11:55 am

Well, I'm an autistic blessed with a cast-iron stomach (and stainless steel intestines-- really, I can eat stuff the dog rejects and never flinch).

However I have the sinus cavities from Hell. From this I have learned that, any time I don't feel good, most of my ASD symptoms get worse. Logical. If I don't have the energy to put into reading stuff, tolerating noises, et cetera, I'm going to be worse at it. I'm going to stress out more and have more trouble showing people the kind of behavior they want to see.

I'm much more likely to hole up in the house, keep the lights off, and bumble through the housework when my head feels like it's simultaneously being inflated on the inside and clamped in a vise on the outside. Those are NOT the days I'm going to pick to take the kids to the park and make chitchat with the other moms.

NOBODY puts their best foot forward when they do not feel good.

So, if something can help control GI issues, chances are it will reduce the perceived severity of autism symptoms, too.


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bryanmaloney
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30 Apr 2013, 9:42 am

The problem in this case is not the scientists. The problem is the worthless morons (aka "reporters") who write the stories for public consumption. This is usually the problem (although there are a few notable exceptions--who always have ended up getting cast out of the scientific community). The actual research looks like it is meant to try to relieve gastrointestinal distress that is often associated with autism. While this is, technically speaking, an "autism symptom", it is not what would be meant by "autism symptom" in the minds of the Great Unschooled. Thus, the waste of DNA who wrote the popular press article has, once again, in a feeble-minded attempt to be an attention whore, spewed rubbish to a world that is so badly-educated that it will credulously accept yet another piece of nonsense.

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Faye712
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02 May 2013, 2:28 pm

DeaconBlues wrote:
I think the "experts" cited here are full of bovine byproduct.


I love the way you put this.


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Livelock
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06 May 2013, 12:09 am

They do not have sufficient evidence to prove this statement. However I haven't seen any to disprove it either so I think it would requires further testing.



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06 May 2013, 3:23 am

Cue massive confusion from the anti-vaccination crowd.


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eric76
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08 May 2013, 5:19 am

AgentPalpatine wrote:
I've never heard of the university, it's apparently in Canada, but one would think we would have heard of it before.


I've run across references to it on a number of occasions.

Have you ever heard of Rockefeller University? That's the one that is hardly ever mentioned. I've seen journal papers from there but have never seen any other articles on it anywhere.



eric76
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08 May 2013, 5:30 am

Nonperson wrote:
It looks like it's actually designed to control diarrhea and constipation, and the idea that it will also cure autism is just wishful thinking on their part.


I suspect that many people hear that it is common with people with Autism and confuse that with being a symptom of Autism. So if you can cure it, you would be curing Autism, at least partially.