Ivermectin found to have "antiviral effect" with Covid virus

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envirozentinel
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05 Feb 2022, 1:54 am

cyberdad wrote:
Fnord wrote:
envirozentinel wrote:
While the vaccine didn't help in a small minority of cases, it's also true to say that some of the strange concoctions Trump endorsed or recommended also caused some deaths in the case of folk who preferred to listen to him than their doctor.
It is better to believe appropriately-trained scientists and medical personnel than bloviated politicians and bloggers.


Yeah I was going to say. Are we living in an alternate universe where moderators are going against qualified medical advice and propping up crackpot theories indirectly encouraging people play russian roulette with their lives?



I think you misunderstood me. Trump (or anyone else who's not a medical professional( had no business to encourage people to drink bleach, horse urine or whatever else they might think up, and indeed should be held accountable for many a death. I was suggesting that these pop-up politicians and other would-be experts stick to what they're good at, if anything...


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cyberdad
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05 Feb 2022, 3:32 am

envirozentinel wrote:
cyberdad wrote:
Fnord wrote:
envirozentinel wrote:
While the vaccine didn't help in a small minority of cases, it's also true to say that some of the strange concoctions Trump endorsed or recommended also caused some deaths in the case of folk who preferred to listen to him than their doctor.
It is better to believe appropriately-trained scientists and medical personnel than bloviated politicians and bloggers.


Yeah I was going to say. Are we living in an alternate universe where moderators are going against qualified medical advice and propping up crackpot theories indirectly encouraging people play russian roulette with their lives?



I think you misunderstood me. Trump (or anyone else who's not a medical professional( had no business to encourage people to drink bleach, horse urine or whatever else they might think up, and indeed should be held accountable for many a death. I was suggesting that these pop-up politicians and other would-be experts stick to what they're good at, if anything...


Ok...um...carry on then...



Brictoria
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05 Feb 2022, 10:06 pm

Slightly off-topic, but interesting anyway: It seems Ivermectin is being looked into as an "anti-cancer" drug, which seems even further from its initial use than treating a viral infection:

Quote:
Graphical abstract

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs.

[...]

Summary and outlooks

[...]

As mentioned above, the broad-spectrum antiparasitic drug IVM, which is widely used in the field of parasitic control, has many advantages that suggest that it is worth developing as a potential new anticancer drug. IVM selectively inhibits the proliferation of tumors at a dose that is not toxic to normal cells and can reverse the MDR of tumors. Importantly, IVM is an established drug used for the treatment of parasitic diseases such as river blindness and elephantiasis. It has been widely used in humans for many years, and its various pharmacological properties, including long- and short-term toxicological effects and drug metabolism characteristics are very clear. In healthy volunteers, the dose was increased to 2 mg/Kg, and no serious adverse reactions were found, while tests in animals such as mice, rats, and rabbits found that the median lethal dose (LD50) of IVM was 10-50 mg/Kg [112] In addition, IVM has also been proven to show good permeability in tumor tissues [50]. Unfortunately, there have been no reports of clinical trials of IVM as an anticancer drug. There are still some problems that need to be studied and resolved before IVM is used in the clinic.

[...]

Most of the anticancer research performed on the avermectin family has been focused on avermectin and IVM until now. Avermectin family drugs such as selamectin [36,41,113], and doramectin [114] also have anticancer effects, as previously reported. With the development of derivatives of the avermectin family that are more efficient and less toxic, relevant research on the anticancer mechanism of the derivatives still has great value. Existing research is sufficient to demonstrate the great potential of IVM and its prospects as a novel promising anticancer drug after additional research. We believe that IVM can be further developed and introduced clinically as part of new cancer treatments in the near future.

Source: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7505114/
Also:
Quote:
In conclusion, we have demonstrated that ivermectin may regulate the expression of crucial molecules Caspase-3, Bax, Bcl-2, PARP, and Cleaved-PARP in the apoptosis pathway by increasing ROS production and inhibiting the cell cycle in the S phase to inhibit colorectal cancer cells (Figure 11). Therefore, current results indicate that ivermectin might be a new potential anticancer drug for treating human colorectal cancer and other cancers.

Source: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8415024/



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05 Feb 2022, 11:36 pm

Returning to the subject, some interesting news just out of Brazil:

Quote:
Background:
Previously, we demonstrated that ivermectin use as prophylaxis for
COVID-19 was associated with reductions in COVID-19 infection, hospitalization, and
mortality rates, and in the risk of dying from COVID-19, irrespective of regularity and
accumulated use of ivermectin, in an observational, prospectively obtained data from a
strictly controlled city-wide program in a city in Southern Brazil (Itajaí, SC, Brazil) of of
medically-based, optional use of ivermectin as prophylaxis for COVID-19. In this study,
our objective was to explore the data obtained from the program to evaluate whether the
level of regularity of ivermectin use impacted in the reductions in these outcomes, aiming
to determine if ivermectin showed a progressive dose-, regularity-response in terms of
protection from COVID-19 and COVID-19 related outcomes.

[...]

Conclusion:

Non-use of ivermectin was associated with a 10-times increase in mortality
risk and 7-times increased risk of dying from COVID-19, compared to strictly regular use
of ivermectin in a prospectively collected, strictly controlled population. A progressive
dose-response pattern was observed between level of ivermectin use and level of
protection from COVID-19 related outcomes and consistent across different levels of
ivermectin use

Source: https://www.researchgate.net/publication/358386329_Strictly_regular_use_of_ivermectin_as_prophylaxis_for_COVID-19_leads_to_a_90_reduction_in_COVID-19_mortality_rate_in_a_dose-response_manner_definitive_results_of_a_prospective_observational_study_of_a



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06 Feb 2022, 1:13 am

^^^
Doesn't Brazil have their own Trump spewing disinformation?


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06 Feb 2022, 1:18 am

Bolsanaro is being held responsible for the 600,000 COVID deaths in Brasil and may be tried in the Hague for crimes against humanity.

https://www.aljazeera.com/news/2021/10/ ... -questions
https://www.theguardian.com/world/2022/ ... oronavirus
https://theconversation.com/bolsonaro-f ... ads-170332

He's also tweeted support for Joe Rogan :lol:



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06 Feb 2022, 2:15 am

cyberdad wrote:
Bolsanaro is being held responsible for the 600,000 COVID deaths in Brasil and may be tried in the Hague for crimes against humanity.

https://www.aljazeera.com/news/2021/10/ ... -questions
https://www.theguardian.com/world/2022/ ... oronavirus
https://theconversation.com/bolsonaro-f ... ads-170332

He's also tweeted support for Joe Rogan :lol:


I was just wondering if he might have had input in that study claiming horse dewormer cures more people with Covid than the actual vaccine.


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06 Feb 2022, 2:40 am

Kraichgauer wrote:
cyberdad wrote:
Bolsanaro is being held responsible for the 600,000 COVID deaths in Brasil and may be tried in the Hague for crimes against humanity.

https://www.aljazeera.com/news/2021/10/ ... -questions
https://www.theguardian.com/world/2022/ ... oronavirus
https://theconversation.com/bolsonaro-f ... ads-170332

He's also tweeted support for Joe Rogan :lol:


I was just wondering if he might have had input in that study claiming horse dewormer cures more people with Covid than the actual vaccine.


Given the study from Brazil which I posted said nothing about the "vaccine", instead comparing the outcomes of people taking regular doses of Ivermectin, compared to those who did not - In fact "vaccine" isn't mentioned anywhere in the study - I'm not sure which study you are referring to: do you have a link to the study you are disparaging, as I'm curious as to what was tested, and how this occurred in it?

Of course, this also makes me wonder - You do realise that it is entirely possible for people who have taken the "vaccine" to need hospitalisation for (and can still dies from) this virus, and that some of these people may want this medication to try and ease their symptoms, don't you?

It's not a binary situation of either "vaccine" or Ivermectin, but not both (or neither).



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06 Feb 2022, 3:00 am

Brictoria wrote:
Kraichgauer wrote:
cyberdad wrote:
Bolsanaro is being held responsible for the 600,000 COVID deaths in Brasil and may be tried in the Hague for crimes against humanity.

https://www.aljazeera.com/news/2021/10/ ... -questions
https://www.theguardian.com/world/2022/ ... oronavirus
https://theconversation.com/bolsonaro-f ... ads-170332

He's also tweeted support for Joe Rogan :lol:


I was just wondering if he might have had input in that study claiming horse dewormer cures more people with Covid than the actual vaccine.


Given the study from Brazil which I posted said nothing about the "vaccine", instead comparing the outcomes of people taking regular doses of Ivermectin, compared to those who did not - In fact "vaccine" isn't mentioned anywhere in the study - I'm not sure which study you are referring to: do you have a link to the study you are disparaging, as I'm curious as to what was tested, and how this occurred in it?

Of course, this also makes me wonder - You do realise that it is entirely possible for people who have taken the "vaccine" to need hospitalisation for (and can still dies from) this virus, and that some of these people may want this medication to try and ease their symptoms, don't you?

It's not a binary situation of either "vaccine" or Ivermectin, but not both (or neither).


The implication is that it's supposed to be better than the vaccine.


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06 Feb 2022, 3:21 am

Somewhat embarrassing, the poor Brasilians never were given a chance
https://brazilian.report/liveblog/coron ... -covid-19/

https://www.businessinsider.com.au/braz ... ?r=US&IR=T

An enquiry finding about Brasil
https://www.bmj.com/content/375/bmj.n2581



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06 Feb 2022, 3:35 am

Brictoria wrote:
Quote:
TOKYO, Jan 31 (Reuters) - Japanese trading and pharmaceutical company Kowa Co Ltd said on Monday anti-parasite drug ivermectin showed an “antiviral effect” against Omicron and other variants of coronavirus in joint non-clinical research.

Kowa did not provide further details. The firm has been working with Kitasato University, a medical university in Tokyo.

Source: https://www.reuters.com/article/health-coronavirus-japan-kowa/japans-kowa-says-ivermectin-effective-against-omicron-in-phase-iii-trial-idUSL1N2UB0AV
Press release and English "Auto-translated" version:


It will be interesting to see the results of the above study, as well as those of this trial which is nearing completion:
Quote:
University of Minnesota researchers expect to finish enrollment this week in the nation's first clinical trial of ivermectin to treat COVID-19, and the study's highly anticipated results could be only a month away.

The COVID-OUT study is reviewing three common drugs, including the antidepressant fluvoxamine and the diabetes treatment metformin, but gained attention for its inclusion of ivermectin. The controversial drug has been championed by opponents of COVID-19 vaccines, despite a warning from the Food and Drug Administration (FDA) that ivermectin is cleared only to treat parasitic infections, head lice and certain skin conditions.

Anti-inflammatory benefits of all three medications prompted the U study, which was delayed by slow enrollment over the summer until the delta and omicron waves of the pandemic emerged. Lead researcher Dr. Carolyn Bramante said the results will provide clinical guidance to doctors who are facing record pandemic cases and to the FDA about whether to authorize the drugs for treatment of COVID-19.

[...]

The U trial is enrolling 1,100 patients with COVID-19 to receive fluvoxamine and ivermectin, alone or in combination with metformin, or a nonmedicating placebo for comparison. The study is tracking whether patients taking the drugs for 14 days avoid hospitalization and maintain healthy blood oxygen levels.

Bramante said the drugs have potential to reduce excessive inflammation — a hallmark of some of the most severe and fatal COVID-19 cases.

Source: https://www.startribune.com/university-of-minnesota-ivermectin-trial-nearing-completion/600139471/
From what I understand, it does show an effect in vitro, but not in vivo. That's not unusual -- many things that show promise in vitro turn out to be useless in vivo.



Brictoria
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06 Feb 2022, 3:40 am

Kraichgauer wrote:
Brictoria wrote:
Kraichgauer wrote:
cyberdad wrote:
Bolsanaro is being held responsible for the 600,000 COVID deaths in Brasil and may be tried in the Hague for crimes against humanity.

https://www.aljazeera.com/news/2021/10/ ... -questions
https://www.theguardian.com/world/2022/ ... oronavirus
https://theconversation.com/bolsonaro-f ... ads-170332

He's also tweeted support for Joe Rogan :lol:


I was just wondering if he might have had input in that study claiming horse dewormer cures more people with Covid than the actual vaccine.


Given the study from Brazil which I posted said nothing about the "vaccine", instead comparing the outcomes of people taking regular doses of Ivermectin, compared to those who did not - In fact "vaccine" isn't mentioned anywhere in the study - I'm not sure which study you are referring to: do you have a link to the study you are disparaging, as I'm curious as to what was tested, and how this occurred in it?

Of course, this also makes me wonder - You do realise that it is entirely possible for people who have taken the "vaccine" to need hospitalisation for (and can still dies from) this virus, and that some of these people may want this medication to try and ease their symptoms, don't you?

It's not a binary situation of either "vaccine" or Ivermectin, but not both (or neither).


The implication is that it's supposed to be better than the vaccine.


Only in your head...

To those who take the effort to read the study, the implication is that for those with serious medical problems caused by the virus, their chance of survival appears significantly better were they to use this medication than were they not to.

By extension, a person who took the "vaccine" and still suffered a serious viral infection would appear to have a chance of survival significantly better were they to use this medication than were they not to.

Again, it is not a difficult concept to understand.



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06 Feb 2022, 3:41 am

Mikah wrote:
Kraichgauer wrote:
I've heard very few defenders of cow dewormer also defend the legitimacy of the vaccine. In fact, they're the same people coming up with the most insane lies about the vaccine.


Roll out Ivermectin using standard doses used in the past and realistically the worst case scenario is a few people get dewormed and it does nothing against the virus. The so-called "vaccines" are a completely different beast.


For the purpose of deworming, aren't they talking about a moderate dose two or three times a year while for the purpose of covid, they want higher doses to be taken daily?



kokopelli
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06 Feb 2022, 3:44 am

envirozentinel wrote:
While the vaccine didn't help in a small minority of cases, it's also true to say that some of the strange concoctions Trump endorsed or recommended also caused some deaths in the case of folk who preferred to listen to him than their doctor.


If his cult really followed him that far, they would have all drank bleach and wouldn't have been around on January 6, 2020 to attack the US in an attempted coup.



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06 Feb 2022, 3:49 am

envirozentinel wrote:
several reliable medical science sources indicating that the vaccine isn't needed if you already had the virus, as you don't get Covid-19 twice.


Not true. Not at all true.

My company has an odd number of people. Since Christmas, everyone but me has had covid. Of those N-1 people, half had had covid before and half had been vaccinated. Every one of those who had covid before had it again. And every one who hadn't had covid but been vaccinated got covid for the first time.

I had covid before (once diagnosed in May 2020 and another probable in October 2020 but not diagnosed) and the Johnson and Johnson vaccine and I didn't get it again.

But if you have reliable citations to actual medical research published in peer reviewed medical journals, please post those citations.



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06 Feb 2022, 4:34 am

kokopelli wrote:
Brictoria wrote:
Quote:
TOKYO, Jan 31 (Reuters) - Japanese trading and pharmaceutical company Kowa Co Ltd said on Monday anti-parasite drug ivermectin showed an “antiviral effect” against Omicron and other variants of coronavirus in joint non-clinical research.

Kowa did not provide further details. The firm has been working with Kitasato University, a medical university in Tokyo.

Source: https://www.reuters.com/article/health-coronavirus-japan-kowa/japans-kowa-says-ivermectin-effective-against-omicron-in-phase-iii-trial-idUSL1N2UB0AV
Press release and English "Auto-translated" version:


It will be interesting to see the results of the above study, as well as those of this trial which is nearing completion:
Quote:
University of Minnesota researchers expect to finish enrollment this week in the nation's first clinical trial of ivermectin to treat COVID-19, and the study's highly anticipated results could be only a month away.

The COVID-OUT study is reviewing three common drugs, including the antidepressant fluvoxamine and the diabetes treatment metformin, but gained attention for its inclusion of ivermectin. The controversial drug has been championed by opponents of COVID-19 vaccines, despite a warning from the Food and Drug Administration (FDA) that ivermectin is cleared only to treat parasitic infections, head lice and certain skin conditions.

Anti-inflammatory benefits of all three medications prompted the U study, which was delayed by slow enrollment over the summer until the delta and omicron waves of the pandemic emerged. Lead researcher Dr. Carolyn Bramante said the results will provide clinical guidance to doctors who are facing record pandemic cases and to the FDA about whether to authorize the drugs for treatment of COVID-19.

[...]

The U trial is enrolling 1,100 patients with COVID-19 to receive fluvoxamine and ivermectin, alone or in combination with metformin, or a nonmedicating placebo for comparison. The study is tracking whether patients taking the drugs for 14 days avoid hospitalization and maintain healthy blood oxygen levels.

Bramante said the drugs have potential to reduce excessive inflammation — a hallmark of some of the most severe and fatal COVID-19 cases.

Source: https://www.startribune.com/university-of-minnesota-ivermectin-trial-nearing-completion/600139471/
From what I understand, it does show an effect in vitro, but not in vivo. That's not unusual -- many things that show promise in vitro turn out to be useless in vivo.

That's why the results of the second study linked (as well as one at Oxford) will be interesting, as they involve testing on patients.

The study I linked a few hours ago from Brazil was also interesting, where they found the use of Ivermectin to have a significant impact on a person's chances of survival if infected. The reported increase in survivability did seem higher than I would have expected, so it will be interesting to compare the results of the other 2 studies with this (although their tests have slightly different aims and criteria).

Either way, it's nice to see people finally beginning to engage in science and investigating possibilities, rather than indulging in politics and pushing claims which suit their biases... As I see it, either the medication doesn't work (no harm done), or it does (meaning those who have been fighting against its use could be responsible for a number of unneccesary deaths) - I'd like to see it (or at least something) work to help those (vaccinated or not) who suffer severe infections, but I'd also hate to think that many people died who otherwise wouldn't have, simply because politics prevented the use of a medication that may have saved them.

It's just a shame it has taken 2 years for people to start seriously investigating medications which may have the possibility of helping those with infections (serious or not) - putting all the focus on "vaccines" instead - particularly as those who have taken the "vaccine" (and "boosters") are still able to become infected, hospitalised, and even die of the virus, and in some poorer countries (where hospital care may be minimal\non-existant) to help people who may become infected before they have a chance at getting a "vaccine" (if they are even available), as well as earlier on in the outbreak before Mr Trump's (operation Warp Speed) "vaccines" were created and people were being hospitalized and dying.