what do u think CAUSES autism
My son had a normal everything no injury at birth no epidural given to me breastfed past a year great diet and still had autism severest form level 3 lowest percentile. Autism runs in both mine and his dad’s side. Eg Every individual family nucleus within his dad’s extended family, even, has 1 severe autistic person.
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Take defeat as an urge to greater effort.
-Napoleon Hill
So, i was doing research on severely neglected children like genie wiley and i found that the behaviour in neglected children were very very similar to autistic children.
and then i was learning about hormone responses, specifically oxytocin, the love hormone, activated during breast feeding and cuddling to ensure bonds in children with their parents.
so when i thought about it, i had a conclusion
WHAT IF, AUTISM IS CAUSED BY A CHEMICAL IMBALANCE OF OXYTOCIN DURING EARLY CHILDHOOD?
think about it, when children are neglected (or denied love and affection) they dont naturally develop social skills. so what if theres a misfiring in the brain of autistic children that can start in early utero that does NOT allow autistic children to receive oxytocin during cuddling and affection or interactions.
theres proabably a ton of holes in this theory and i dont know what would cause this chemical imbalance but its just a little thought i had
It's quite an accurate thought that you had.
There's evidence to support it.
A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder
https://doi.org/10.3389/fnmol.2018.00027
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00991
I don't ever agree with the idea that it is food, parental trauma, anything but the way the brain was coded to develop. What I took from the article that made sense to me is that because autistics take in so much sensory and emotional empathy info and can get so overloaded, it translates into what could be perceived by others as ptsd symptoms. Different source, similar external symptoms.
It runs in my family for generations, from my great grandpa to grandpa, to my dad, to me, and my sons. Everyone seemed to have a brilliant mind which compensated for their lack of social skill (but there were arranged marriages), everyone except my little son, who has a regular brain and exhibit more classic autism symptoms. I do think toxic environment can exacerbate symptoms, and a supportive family can make one feel quite normal. Overall I'm not too concerned about what caused it, I doubt we can eliminate autism easily.
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AQ score: 44
Aspie mom to two autistic sons (21 & 20 )
It is now thought by geneticists that DNA mutations can occur to the foetus after conception and before birth. This is now thought to explain why identical twins can be significantly different - and re autism, why one identical twin can be on the spectrum and the other not. The old assumption that both are subject to exactly the same conditions is a developing area of inquiry, and it is a very interesting one.
In my only family there is evidence of AS for five generations, the two before mine and the two after mine, and in the fifth generation (my grandchildren) there are one set of fraternal male twins. Both are AS though they manifest it in different ways. One is quite extroverted, very gifted in maths, science and athletic ability, and highly competitive and independent; the other is introverted with average scholastic ability, profoundly interested in the natural world, a gentle soul who does his best in everything and needs a lot of emotional support and reassurance. (Their parents are my NT daughter and my AS son-in-law), but as genes are inherited as well from grandparents, and of the 4 grandparents, 2 of us ,( the paternal grandfather and myself, the maternal grandmother) are on the spectrum, so I would say that in our family AS arises from genetics rather than any mutation after conception.
However given the explosion of new genetic knowledge in the past 15 years, I would think that the next ten years will see some extraordinary progress in building on the work to date in this field.
The mutation after conception theory is more compelling in the case of those families in whom no-one has AS and then it suddenly appears in one child. I look forward to more knowledge developing in this body of research.
So, i was doing research on severely neglected children like genie wiley and i found that the behaviour in neglected children were very very similar to autistic children.
and then i was learning about hormone responses, specifically oxytocin, the love hormone, activated during breast feeding and cuddling to ensure bonds in children with their parents.
so when i thought about it, i had a conclusion
WHAT IF, AUTISM IS CAUSED BY A CHEMICAL IMBALANCE OF OXYTOCIN DURING EARLY CHILDHOOD?
think about it, when children are neglected (or denied love and affection) they dont naturally develop social skills. so what if theres a misfiring in the brain of autistic children that can start in early utero that does NOT allow autistic children to receive oxytocin during cuddling and affection or interactions.
theres proabably a ton of holes in this theory and i dont know what would cause this chemical imbalance but its just a little thought i had
It's quite an accurate thought that you had.
There's evidence to support it.
A Review of Oxytocin and Arginine-Vasopressin Receptors and Their Modulation of Autism Spectrum Disorder
https://doi.org/10.3389/fnmol.2018.00027
https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00991
Yes I also thought this was fascinating stuff too. I agree, lack of ocytocin could play a significant role.
As could too much cortisol (also often linked to e.g. neglect or other stress).
Sue Gerhardt, she's a neuroscientist I really respect and she writes in detail about this stuff in her book "Why Love Matters: How affection shapes a baby's brain".
The release of these hormones varies hugely from person to person it seems naturally, as you say... but here I get really interested in epigenetics too! Too much cortisol production/release and too little ocytocin could e.g. be due to genetic expression/repression from previous generations (so it does not even stop at what your environment was from conception on - don't forget in utero experiences are going to have a major effect on e.g. hormone balance).
So basically, experiencing trauma can literally change your DNA and manifest in HERITABLE traits. Not many people are aware of this. In addition to this... already being traumatized (or your parents or grandparents) predisposes you to suffer trauma far more readily... your brain has literally been rewired (the limbic system: amygdala etc.)
No wonder we find it so hard to distinguish between what is 'genetic' (though what we generally like to mean by this is that it is kind of 'pre-ordained'

Environment/experience drives evolution.. I think we have known this since Darwin. So the line gets a little bit fuzzy - quite rightly, it should be VERY fuzzy ! !!
The article on ocytocin is really interesting, thanks for that.
Last edited by katy_rome on 06 Mar 2018, 12:46 pm, edited 5 times in total.
Yes. That's what I mean by the 'genetic predisposition'. So you have all the symptoms of HFA - that is, savant abilities, hyperfocus, etc. The positive stuff. Hyper-empathy... (and interesting manifestations of that)
And that is the part that I reckon is absolutely genetic. It's the brain wiring - as I mention in the article, hyperconnectivity in the brain. That's cool stuff.
Only that this incredible fine-tuning, and sensitivity - through senses and brain stimuli.. can so easily lead to experiences being lived as traumatic, hence the host of post-trauma symptoms.
If not...
well, it seems a most astounding coincidence, that the rest of the symptoms (besides this hyper-connectivity in the brain... hyper-perception, hypersensitivity etc. - leading to savant abilities and so on) are literally identical to post-trauma.
Sorry, you guys are probably going to want to lynch me soon (but I have to say I am getting SO MUCH out of your comments and feedback, it really means a lot to me!! !!).. but YES I totally agree and.... um.. did you get to take a look at my article?
http://www.dos-and-donts-autism.com/autism-causes.html
High IQ being the brain wiring (genetic) part... definitely.

Myself and my son both have autism although his is severe, and we both have the same genetic mutation that both his dad n brother do not have. It is the ‘9th chain’ apparently? They don’t know much about it.
If anyone knows anything about genetic mutations and autism plz enlighten me.
Keeping in mind I’m not too smart to know the scientific details.
_________________
Take defeat as an urge to greater effort.
-Napoleon Hill
If anyone knows anything about genetic mutations and autism plz enlighten me.
Keeping in mind I’m not too smart to know the scientific details.
I know NOTHIN about 9th chain - I'm sorry! Anyone?
If anyone knows anything about genetic mutations and autism plz enlighten me.
Keeping in mind I’m not too smart to know the scientific details.
I have no idea sorry but did you all get genitically tested?
_________________
"I will file you under "L" for people I love most. "
If anyone knows anything about genetic mutations and autism plz enlighten me.
Keeping in mind I’m not too smart to know the scientific details.
I have no idea sorry but did you all get genitically tested?
In a way they said smthing abt that genome or sequence or whatever not being known so the deletion effect was unknown
They tested to check fr various conditions
_________________
Take defeat as an urge to greater effort.
-Napoleon Hill
I just wrote this article on the causes of autism. Interested to hear people's thoughts on it.
A quarter-century ago, we had to make grim jokes about our "grey-on-silver" screens. The modern LCD is a triumph of technology, so I refuse to read it when the contrast is turned down to eye-strain levels.
Thanks for alerting me to this. I've changed it now, made the text darker (I just used a template, I'd never looked at it e.g. on an ipad before... and you're right... it was hard to read!)
So - it wasn't just the environment but also having the predisposition... would that be how you see it, more or less?
It's actually possible for identical twins to be one autistic and one not. Their DNA is (obviously) identical too, so what would explain that?
Maybe they are both predisposed but only one gets exposed to a high enough level of... something... that then tips the balance and makes that one become autistic.
In my only family there is evidence of AS for five generations, the two before mine and the two after mine, and in the fifth generation (my grandchildren) there are one set of fraternal male twins. Both are AS though they manifest it in different ways. One is quite extroverted, very gifted in maths, science and athletic ability, and highly competitive and independent; the other is introverted with average scholastic ability, profoundly interested in the natural world, a gentle soul who does his best in everything and needs a lot of emotional support and reassurance. (Their parents are my NT daughter and my AS son-in-law), but as genes are inherited as well from grandparents, and of the 4 grandparents, 2 of us ,( the paternal grandfather and myself, the maternal grandmother) are on the spectrum, so I would say that in our family AS arises from genetics rather than any mutation after conception.
However given the explosion of new genetic knowledge in the past 15 years, I would think that the next ten years will see some extraordinary progress in building on the work to date in this field.
The mutation after conception theory is more compelling in the case of those families in whom no-one has AS and then it suddenly appears in one child. I look forward to more knowledge developing in this body of research.
^^ identical twin differences explained well here by B19. Absolutely fascinating reading about your family B19. How do you feel diagnosis and support has changed over the generations?
_________________
"I will file you under "L" for people I love most. "
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