Does anyone know of any fictional characters with AS?

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I take non-humans out of the picture altogether. What is neurotypical for humans may have absolutely no reference to other species. (With apologies to the author of All Cats Have Asperger's Syndrome)

I think the more interesting character to examine from the Star Trek universe is Reg Barclay. Again, we have a character with a clinically significant social impairment. There is no solid evidence one way or another, but it is open to speculation.

I'm watching a kid's show called Wimzie's House right now (becuase there is nothing else on) and this one character by the name of Jonas is VERY aspie-ish.

Kim Ross from the webcomic Dresden Codak. She is never stated outright to have AS/high functioning autism, although I think she does.
http://dresdencodak.com/2009/04/19/onald-creely/

Dr. Zack Addy from Bones perhaps?

I must say Hank Hill especially after watching a newer episode where he is traumatized by the seating arrangements in the town's new restaurant. Where strangers will out of nowhere try to sit next to and talk to you.

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I've started reading House Rules by Jodi Picoult, about a family with an 18 year old Aspie boy. I'm ambivalent about it -- she seems to have done all her interviewing with parents found through Autism Speaks and though I think she's making an attempt to be balanced, well, consider the source. The mom seems to be a total curebie... reading about her husband leaving her, I can't help thinking, "hell, I would have left her too."

But I'm not that far in yet and other perspectives may yet appear.

House is the only one that I can think of, right now.

Whatever! Not that I don't believe you. I do. But Sheldon is completely an aspie, whether the producers think so or not. I wonder what the writers say. Intentionally or not, they have created a character that many of us with AS identify with. I see certain aspects of myself in Sheldon every week and revel in the humorous portrayal of a brilliant but antisocial character. The producers may say Sheldon is not on the spectrum, but I think many fans would disagree. I think diagnosing Sheldon would be a mistake and out-of-character for the show, but I'm going to go on thinking of Sheldon as an aspie!

To be honest, Sheldon doesn't seem Aspie to me. He doesn't know the proper things to say to people because that sort of thing has never interested him, and he has always been buried in his scientific pursuits, since he was a child, so never had a chance to learn social interaction. But when he does interact with people he is very charming and genuinely animated, and makes good eye contact. Plus he is interacting with other people all the time! He never needs to withdraw, doesn't have meltdowns, isn't unnerved by sensory stimuli, etc. I do think he has OCD though.

i have to disagree bee, sheldon is extremely aspergian. i know the creator when asked said "my opinion is his mom never got a diagnosis so i just don't know". in one interview jim parsons said sheldon "really could not be anymore aspie, could he." he doesn't know the proper things to say because, by his own admission, most of the human experience escapes him. he does make intense eye contact, but it is still inappropriate eye contact. not all aspie present this symptom by avoiding eye contact. you called his interaction with people charming and genuinely animated, when most of the humor is focused around his callous interactions and the oddness of his behaviors. these judgements coming from the collective characters of weird super nerds. the character is also looking constantly for solitude and to withdraw. no one is allowed in his room, he sits alone in an office all day thinking about whatever floats his boat, and there have been numerous episodes focusing around sheldon getting solitude from everyone, being so happy about it, and it being ruined. and if you saw the epsidoe monday going back seven years to when he and leonard first met the writers added fuel to the fire... i think it had to be intentional at this point. but that's just my perception.

Yeah, I have to agree on second thought. I think you're right.

He does have more friends than I do, though, and he hangs out with them an awful lot!

This may've been mentioned in the previous posts, but I didn't check.
Josh Hartnett's character "Donald" as well as the character who plays his opposite in the movie "Mozart and the Whale." There's also that movie called "Adam."

Hodges from "CSI Las Vegas". He is ALWAYS putting his foot in his mouth!

Recently purchased and watched the film Re-animator and think the main character Herbert West is an Aspie. Anyone who has watched the movie would agree there's is traits there admit it.

L and Near from Death Note
Edward from Cowboy Bebop
Rei from Evangelion
Almost all vulcanians on Star Trek