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Jakki
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31 Dec 2021, 5:04 am

SandWitch wrote:
I would jighly reccomend regulated pharmaceutical grade medical cannabis, if legal were you live.

It helps me out, to reduce burnout and sensory overload for me and gives me relief from depression and anxiety.

Also, it stops my pyshical and diaphram/breathing and verbal tics.


have tried this in the past ( pharmacuetical grade cannibus) specifically Indica Strain, it did help me sleep after about a hour . But as with all medications there is a risk of developing a tolerance to it as a medication, from my experience . After repeated use for a extended period of time .
In regards to 5-htp did develop a tolerance after several weeks of nightly use . But your mileage may vary .Another good sleep aide, which side effects maybe keeping a person calmer is using 500 mg of the amino acid, tyrptophan nightly . Which i did not notice a tolerance too .These are just my own experiences . :mrgreen:


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auntblabby
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31 Dec 2021, 12:17 pm

the following is an adult subject, so i'm warnin' y'all off in case it offends your sensibilities, but it really works well for me, so if you are curious, skip past the boundary layer-
*********************************************************************************************************************************************************************************************************************************************************************************************
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/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\/\
<<><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><<<><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><<<><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><><>
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i find that if i give myself 3-5 orgasms of the highest quality [augmented by good porn] up to 5 or 6 times per day, it improves all symptoms including pain and depression and inattention and insomnia, without any Pmeds, this regimen is its own form of pmed. 8) :idea: :mrgreen: :jester: :heart: :D :wink: :!: :arrow: :) :cheers: :star: :drunken: :pr: :pl: :salut: :sunny: :bounce: :cherry: :cat: :santa: :rendeer: :queen: :king: :joker: :jocolor: :farao:



SandWitch
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08 Jan 2022, 7:30 pm

Jakki wrote:
SandWitch wrote:
I would jighly reccomend regulated pharmaceutical grade medical cannabis, if legal were you live.

It helps me out, to reduce burnout and sensory overload for me and gives me relief from depression and anxiety.

Also, it stops my pyshical and diaphram/breathing and verbal tics.


have tried this in the past ( pharmacuetical grade cannibus) specifically Indica Strain, it did help me sleep after about a hour . But as with all medications there is a risk of developing a tolerance to it as a medication, from my experience . After repeated use for a extended period of time .
In regards to 5-htp did develop a tolerance after several weeks of nightly use . But your mileage may vary .Another good sleep aide, which side effects maybe keeping a person calmer is using 500 mg of the amino acid, tyrptophan nightly . Which i did not notice a tolerance too .These are just my own experiences . :mrgreen:


Ya, to each their own.. at least it helped you a little, is better than none at all.

Tolerance build-up, for me is easily reduced by adjusting my intake a little, temporarily; then back to being baked.

i mostly use my indicas at night to, since it's when I'm usually active.

I don't f**k with sustivas in the daytime, unless, I want to induce an instant sensory overload, paranoia- driven meltdown.

I'll look into shopping for 500 mg of the amino acid, tyrptophan, after an internet deep dive on the component and what it's comprosed of and if it will benefit my specific needs. Thanks for the tip.



Jakki
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08 Jan 2022, 9:19 pm

Happy to share ……. Lots of trial and error went into those suggestions over several years . Theanine is another amino acid that helps sleep . But not as good as the experiences with tryptophan .


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12 Jan 2022, 8:55 am

Introducing Spectrum’s Autism Drug Trial Tracker

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Today we released the first iteration of our Autism Drug Trial Tracker, which provides interactive, curated information on more than 200 clinical trials for autism and related conditions. The data powering the web application are freely available, as is the code that was used to scrape the data.

We intend to update the tracker monthly, as new data become available. If you have feedback or suggestions, or if you would like to see additional features, please contact us at [email protected].

You can use the interactive web tool to filter the dataset based on sponsors, enrollment count or a slew of other factors. And the filtered data can be plotted in one or two dimensions, or downloaded directly to a .csv file. We hope this tool facilitates discoveries and helps to bring the evolving landscape of autism drug treatment into sharper focus.

Despite hundreds of clinical trials and dozens of drugs tested for autism, none are approved to treat the condition’s core features. Just two drugs — the antipsychotics risperidone and aripiprazole — have been approved by the U.S. Food and Drug Administration (FDA) to treat autism-related irritability.

The Autism Drug Trial Tracker is not exhaustive. We consulted with clinicians and researchers, some of whom have designed and performed their own clinical trials for autistic people, to choose our data inclusion criteria. We limited our dataset to a subset of trials scraped from the ClinicalTrials.gov results database, which was launched in September 2008 and may not include trials from before that year. We limited our data to include only placebo-controlled trials that are phase 2 and higher, and to exclude trials that are based solely on behavioral interventions. We also excluded drugs tested in combined phase 1 and 2 trials, and we only considered trials involving people diagnosed with autism or a short list of syndromic forms of the condition.

About 65 percent of the trials in the dataset are for autism, 13 percent are for fragile X syndrome, and about 8 percent are for tuberous sclerosis complex. Academic universities and hospitals sponsored more than 60 percent of the trials.

The most commonly tested drug in our dataset is oxytocin, with 19 clinical trials over the past two decades. A large, placebo-controlled trial published in October found that oxytocin was not more effective than placebo at increasing social behaviors in autistic children.

Aripiprazole and risperidone follow oxytocin in total trials tallied, with eight and seven, respectively.

Nearly 10 percent of all trials in the tracker have announced a termination for one reason or another. The most common reasons are a failure to recruit participants, financial difficulties and a lack of efficacy.

For each clinical trial, we curated information that is not available on ClinicalTrials.gov. For instance, we independently determined whether each drug was previously approved by the FDA for a different condition. We identified trials with a ‘combined modality’ that tested multiple drugs at once or mixed a drug intervention with a behavioral therapy. And we also identified peer-reviewed articles for each clinical trial, where available on PubMed, and added descriptions of each drug’s biological mechanism.


Autism Drug Tracker: User Guide

Autism Drug Trial Tracker


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15 Jan 2022, 6:46 am

It's only my first day on it, but Adderall has been amazing so far.


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Jakki
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15 Jan 2022, 6:28 pm

Dox47 wrote:
It's only my first day on it, but Adderall has been amazing so far.


Been considering trying it , but am pretty sure my doctor would not approve it.. Have not discussed my diagnosis with him. And i do not know if he has treated Aspies before, he has treated alot of varying conditions that i know of.
Pretty sure it would be beneficial to me.


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Dox47
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16 Jan 2022, 7:55 pm

Jakki wrote:
Been considering trying it , but am pretty sure my doctor would not approve it.. Have not discussed my diagnosis with him. And i do not know if he has treated Aspies before, he has treated alot of varying conditions that i know of.
Pretty sure it would be beneficial to me.


Might be worth a try, I certainly don't have an ADHD diagnosis, I just had a conversation with my meds manager about how nothing has ever worked for me out of any of the anti-depressants, and maybe we were going at things backwards because my biggest issues are all related to poor executive function, and he was just like "sure" and wrote me the scrip.


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Jakki
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16 Jan 2022, 8:44 pm

Thank you ..... :D


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auntblabby
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17 Jan 2022, 1:33 am

Jakki, i was on a timed-release form of methylphenidate [basis of adderal] and it made me feel subjectively more "with it," but it also made me very hot-tempered, so YMMV. as a bonus i lost 20#.



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17 Jan 2022, 1:51 am

Thank you ..... Auntblabby do not need to aggravate my temper or lose weight ,
but i could use a step up in my executive function very badly ???


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auntblabby
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17 Jan 2022, 2:06 am

Jakki wrote:
Thank you ..... Auntblabby do not need to aggravate my temper or lose weight ,
but i could use a step up in my executive function very badly ???

with one notable side effect [GERD, but you may not necessarily get that depending on your dietary habits], Strattera [Atomoxetine] worked very well for me, it came on like a lamb, very subtly but about a week after i started taking it, i woke up without anxiety and felt subjectively calm and normal, that was a novel experience for me. it is an expensive drug and your insurance may or may not carry it.



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17 Jan 2022, 1:06 pm

Dear Auntblabby is Strattera the same as Adderal ? or a close relative.


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auntblabby
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17 Jan 2022, 3:56 pm

Jakki wrote:
Dear Auntblabby is Strattera the same as Adderal ? or a close relative.

strattera [atomoxetine] is not an amphetaminic salt like Adderal, it is not methylphenidate. it is a Selective Norepinephrine Reuptake Inhibitor that works by increasing the amount of norepinephrine, an important chemical in the brain, which seems to help ADHD [and AS in my case] by increasing attention span and reducing impulsive behavior and hyperactivity. it had the effect of calming me simultaneously with increasing my alertness which was heretofore a novel thing for me [IOW i was previous to this, either keyed up and jittery, or calm and sleepy with no middle ground]. it really improved my mental health. the clouds parted and the sun shined, very gently :sunny: it didn't cure my AS but took the rough edges off of it, same for the ADHD, it shoved it into the background. i had much more energy and no more depression. only side fx were the aforementioned GERD [hadda take antacids/acid killers] and a peculiarly male "ooze." women presumably won't have that particular side effect.



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17 Jan 2022, 8:02 pm

Thank you very much . For this information Auntblabby . !Will see what my Doctors might be willing to work with me on.
But am concerned , it seems maybe you have contracted the OOZE . have you warned the neighbours , possibly the Authorities so people know to flee the area . be careful please if it gets out of control it may envelope your entire living structure ... 8O :wink:

btw seriously Thank You. :D


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auntblabby
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17 Jan 2022, 8:28 pm

^^^prego. no more ooze since group death and the other health insurers ['cept for cadillac plans like top-tier BC/BS] stopped including it in their formularies due to its cost.