People I worked with at the fast food place used to have such a shocked look on their faces when I told them I have never been piss-ass drunk. Never will be either. Nothing against alcohol per se, just don't see the appeal in getting so wasted you lose control of your senses, your environment, what happens to you, etc.
Also beer seems to give me sore joints. Around the time when my doctor diagnosed me with CFS, I mentioned this to him and he said alot of people with CFS are more sensitive to alcohol than others. I just don't drink it much anymore. I might occasionally have a quarter glass of red wine if I'm having a nice dinner at someone's house but that is a rare occasion. Even that little I'm sensitive to - I get quite a buzz from a tiny amount.
I am super-extra sensitive to marijuana as well. I only need a crumb of brownie or cookie to help me fall asleep (not even every night either, just on the nights where I feel my insomnia is going to be bad)
P.S. I have my medical marijuana prescription so I'm all legal 
_________________
Diagnosed "Asperger's to a moderate degree" April 7, 2015.
Aspie score 145 of 200
NT score 56 of 200
AQ score: 47
RAADS-R score: 196