Absolutely.
I've always had two groups of companions (I'm hesitant to say "friends" because I don't know how they view themselves and I'm just starting to learn how very much I may misinterpret forms of companionship).
One is those much younger than I (as an example, my closest "friends" in my old neighbourhood are those I used to babysit as children, who are 6-11 years younger; the only companions I have in my current neighbourhood are the neighbours' grandchildren, the oldest of whom is 13 years my junior).
The other is those much older than I (that is, teachers, professors, the parents of the aforementioned children; in general, those who, now that I am a young adult, are at the very least middle-aged).
I can count on the fingers of one hand the people my age whom I would consider friends, or even companions in the same sense of the word as I have been using. Not only that, but of those with whom I enjoy spending time, almost all have features of the autistic spectrum (though perhaps not enough for a diagnosis) or other issues with similar socio-emotional results.
Furthermore, although I am female, almost all of my friends (for the entirety of my life) have been male.