Endings to long series. Like Telltale's Sam&Max, or their Walking Dead series, letting go of characters you've been attached to. I was devastated finishing Mass Effect 3, seeing all those characters die and then the whole mass relay system be destroyed that made the Mass Effect universe possible, meaning there would be no more.
I think I shed a tear or two at the end of Grim Fandango.
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Enjoy the silence.