There is no such thing as before time, because "before" is a concept of linear time. If you're outside of linear time then it doesn't apply.
If the universe was caused by some sort of brane collision, that just means that the whole of reality, is much more vast and complex than we can comprehend currently, and is larger than just the universe. You would still have to deal with the problem of the beginning of this greater reality, if linear time or causality even apply to it (if they don't then conceptualization will be extremely difficult).
I think people have a hard time grasping the concept of true nonexistance. But there are only two options to reality, either it is bounded, in which case we have to grasp that there is literally nothing beyond those boundaries, or it is not bounded, in which case we have to grasp that there are no limits to it all in any sense. Both concepts are alien to the way we think and our experience of reality on a personal level, but logically, it must be one of the two.