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Have you explored/researched the broad autism phenotype thoroughly?
Yes 47%  47%  [ 14 ]
No 53%  53%  [ 16 ]
Total votes : 30

kraftiekortie
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17 Dec 2014, 11:09 am

As an "idiopathic" autistic person, I am most aware that one must look at all possibilities. However, one must also consider the merit of these possibilities.

I just don't know where I got my autism from! LOL



btbnnyr
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17 Dec 2014, 2:56 pm

I have not noticed particular schism in research community between people who work on autism using different approaches, such as brain vs. cell.
Usually, the different researchers have backgrounds have in different areas, so they apply their knowledge area when studying the common topic of autism, which is only one of their topics of study.
I work on human brain, but I made sure to meet with researchers studying autism using cellular/animal models approach.


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B19
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17 Dec 2014, 4:12 pm

Good stuff. However it pans out in 40 years' time - who knows - it's possible that what is taught now will be very different from what will be accepted then. If we look back even 30 years, the state of ASD knowledge then seems so limited to us from here; I suspect that the same cycle will repeat in the next 30, whatever it turns up, whether paradigms change or not. Hope I am here to see it.



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17 Dec 2014, 4:31 pm

My father is not diagnosed for ASD, but I think he would get a diagnosis for ASD.


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kraftiekortie
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17 Dec 2014, 6:09 pm

In autism terms, 30 years is eons. 30 years ago, autism was a much "narrower" disorder than it is today.

However, many clinicians still stick to 30-year-old notions--such as when one might say: "you can't have autism, you show too much empathy for people."



B19
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17 Dec 2014, 6:14 pm

Yes, spot on Kraftie.



Eloa
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17 Dec 2014, 6:52 pm

kraftiekortie wrote:
In autism terms, 30 years is eons. 30 years ago, autism was a much "narrower" disorder than it is today.

However, many clinicians still stick to 30-year-old notions--such as when one might say: "you can't have autism, you show too much empathy for people."


Sometimes I wonder if only "one sort of autism" exists,
one cause of it.
Some people say, that after changing their nutrition their symptoms lessened.
I read about monozygotic twins with autism but vey different symptoms of autism,
though the core symptoms were present, but one was inclined to very loud sound, the other one could not even bear very light sound.
Diary changes had diffrent outcomes in both.
I also wonder if when in the autism spectrum is referred to "low functioning autists" which means autistic persons with intellectual disability if in the neurotypical world people with intellectual disability are referred to as being "low functioning neurotypical", which won't be the case, as neurotypical persons do not refer to themselves as neurotypical persons.


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B19
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17 Dec 2014, 7:23 pm

I think that's a very valid avenue to keep an open mind about. There is so much we don't know. Common cause has been assumed for all parts of the spectrum for the last two decades, whatever that cause is. This may or may not be true. It is continually stated as an absolute fact, in articles, the media, everywhere. The assumption could be correct, equally, it may not be.



kraftiekortie
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17 Dec 2014, 7:36 pm

Eloa is quite right, I believe.

There are many different causes of autism, I believe.

I would bet that, one day, we might be referring to the Autisms, rather than the singular Autism. I suppose we are sort of doing that now with the term "autistic spectrum."



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17 Dec 2014, 10:53 pm

As we learn more about different causes of autism, I think that autism will narrow rather than broaden, such that disorders like Rett go off autism spectrum (already happened), then Fragile X autism-like symptoms currently diagnosed as autism being distinct from non-Fragile X autism (past few years research trending this way), then same for other genetic disorders, perhaps same idea for environmentally-induced symptomps, etc etc etc, until what is autism is caused by combinations of common genetic variants causing similar traits in general population. There will also be improvements distinguishing autism from intellectual disability and autism from neurotypical, so boundaries of autism will change at low-functioning and high-functioning ends. I think the broadening phase was the DSM-IV, and near future is refining/distinguishing phase.


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17 Dec 2014, 11:28 pm

btbnnyr wrote:
As we learn more about different causes of autism, I think that autism will narrow rather than broaden, such that disorders like Rett go off autism spectrum (already happened), then Fragile X autism-like symptoms currently diagnosed as autism being distinct from non-Fragile X autism (past few years research trending this way), then same for other genetic disorders, perhaps same idea for environmentally-induced symptomps, etc etc etc, until what is autism is caused by combinations of common genetic variants causing similar traits in general population. There will also be improvements distinguishing autism from intellectual disability and autism from neurotypical, so boundaries of autism will change at low-functioning and high-functioning ends. I think the broadening phase was the DSM-IV, and near future is refining/distinguishing phase.


I also think autism will narrow, and conditions that present like autism will become known and others more distinguished. No idea how long that will take to happen though.


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btbnnyr
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17 Dec 2014, 11:48 pm

There was study about prevalence of BAP in families of HFA vs. LFA children, and finding of higher prevalence for HFA, likely inherited genetic variants contributing to BAP and HFA. In LFA, the rate of de novo mutations (new mutations in children not found in parents) is higher than both HFA and NT, which are the same on this measure.

Estimates of prevalence of "complex autism", referring to autism-like symptoms accompanied by varied neuro/non-neuro symptoms and possibly distinct symptoms specific to genetic disorder like Rett, are 20% of autism spectrum, and it is this group (more like many small subgroups) that may be distinguished first.


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btbnnyr
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18 Dec 2014, 12:43 am

I am wondering if anyone seems to have inherited all the different autistic traits of both parents, as I seem to have inherited.
The individual autistic traits seem to have gotten stronger from them to me too.
Then, there was the language development delay that neither of them had, that was mine, all mine, my precious.


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18 Dec 2014, 12:55 am

You can probably count me in on that one.



kraftiekortie
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18 Dec 2014, 10:08 am

I'm a purely idiopathic autistic person.



Norny
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18 Dec 2014, 11:19 am

kraftiekortie wrote:
I'm a purely idiopathic autistic person.


Would you have considered yourself LFA when you were young? If so that seems consistent with what btbnnyr posted about the genetic traits typically leading into a child with HFA.

My friend was LFA when he was young, and his parents do not have many autistic features. He has deemed his mum 'slightly cold' but that's all.

In my family there have been sensory sensitivities, though not to the extent of hyper or hyposensitivity. There are visual/spatial deficits, related disorders (OCD, potentially ADHD, anxiety etc.). I wonder if it would be more likely down the track for my family to have a child with LFA or HFA. Impossible for me to figure out. :wink:


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