Females are less likely to be diagnosed and there are more expectations on us to be fluffy headed, social, and nurturing. I think girls have to fly in the face of convention more when they have AS. If you're a guy, and you're really well informed on a subject, it's great. Try doing the same as a girl..... it isn't the same.
Girls are also somewhat more likely to be molested or raped, and this IS an issue for Aspies because we are less likely to realize we are in danger from the person (especially if it's an aquaintance or family member) until it is too late.
I think that it has been documented that aspie males have more problems with aggression and rages (but I have seen aspie girls with this problem too!).