For me, mostly sports - I could not catch a ball and took up bowling when I was in school. As for driving, I have no problems during the day, though sometimes driving at night can be difficult, especially when looking in the rear-view mirror to ensure that it is safe to change lanes, etc.
I used to believe that I had no depth perception, but I don't think that is completely true anymore - I've noticed some 3D effects in 3D movies and when playing with a Nintendo 3DS. Other times I can use parallax and reference points to determine distance - when riding a bike, for example, I can duck my head just in time to avoid a low branch.
My eyes have been a bit "off" ever since I was born, but I have adapted and can actually focus on objects using either eye
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"Tongue tied and twisted, just an earth-bound misfit, I" - Pink Floyd
(and then the tower cleared me for take off)