I'm on record at my pharmacy as needing easy-open caps.
Caps on OTC meds can still be a b***h to open, though; once the lid's pried off, I can pour them into an empty Rx bottle with an easy-open cap and a masking tape-and-Sharpie label.
I keep my daily meds in one of those big pill boxes with many lids; AM/Noon/PM/HS down one axis; Mon-Sun across the other. If I can't quite remember whether or not I took this morning's meds, I can look and see if there are any pills in the "SUN AM" compartment. It keeps me from accidentally OD'ing.
I've also got a talking Echo "Dot" device, that aside from other 'executive function' capabilities, verbally reminds me to take my meds at programmed times, and a little while later asks if I'm quite sure that I did. That's been really helpful to me in reaching 100% compliance (and avoiding scolding).
I go with the absolute least amount of pharmaceuticals which I can get away with.