cyberdad wrote:
Wait, African people have no Neanderthal or Denisovan DNA but autism is still prevalent in Africa??
Some Africans have some Neanderthal ancestry, but it's attributed to H. sapiens with Neanderthal ancestry migrating back into African, rather than direct interactions.
I haven't come across anything confirming Denisovian ancestry in Africans, the assumption appears to be that there is none.
https://www.newscientist.com/article/22 ... re-anyway/https://www.cell.com/ajhg/fulltext/S0002-9297(19)30426-4
https://phys.org/news/2016-03-world-nea ... odern.htmlhttps://academic.oup.com/gbe/article/15 ... ogin=falseAccording to another article African and East Asian populations have undergone different selective pressures on SLC30A9.
Quote:
Intriguingly, we found that SLC30A9 was underlying natural selection in both East Asians (EAS) and Africans (AFR) but in different directions. Notably, a non-synonymous variant (rs1047626) in SLC30A9 is almost fixed with 96.4% A in EAS and 92% G in AFR, respectively. Consequently, there are two different functional haplotypes exhibiting dominant abundance in AFR and EAS, respectively.
https://www.nature.com/articles/srep09658That doesn't get into the origins of the variations, but does seem to state pretty strongly that they're not usually carrying the same SLC30A9.
This article also suggests it's not a cold adaptation but instead an adaptation driven by differing amounts of zinc available for absorption from local foods.
Regardless of the selection mechanism, if some populations produce autistic people but lack the Denisovian SLC30A9 variant, we can preclude SLC30A9 variability as a primary cause of autism.
Further, if the zinc transfer gene is a significant contributor, (my completely uneducated guess is that) we can probably offset the problems it does cause with zinc supplements.
_________________
Watching liberals try to solve societal problems without a systemic critique/class consciousness is like watching someone in the dark try to flip on the light switch, but they keep turning on the garbage disposal instead.
戦争ではなく戦争と戦う
05 Feb 2024, 3:56 pm
