First lets explain in basic terms one half of calculus - differential calculus, or the portion of calculus dealing with derivatives.
From geometry, you should know that at any point on a circle there exists a tangent line that touches only that one point on the circle, and is also perpendicular to the radius line from the center of the circle to that same point on the circle:
Ok, well, other curves besides circles can have tangents too. For instance, the figure below illustrates the tangent line to a parabola at a given spot on the parabola:
Now, think back to the equation for a line, which is generally stated as y=mx+b. The important thing here is that m is the slope of the line. The slope of the line is expressed as the ratio of the rise of the line to the run of the line. For instance, a line with a slope of 5/2 rises 5 units for every 2 units moved to the right.
So a derivative of a function is another function that tells you the slope of the tangent line on the original function for any value of x.
For instance, y=x^2 is the equation of a simple parabola, as above.
The derivative of y=x^2 is y=2x (take my word for it, how I found that is unimportant for this discussion).
What this tells us is that when x is 0, for instance, the slope of the tangent line on the function y=x^2 is 0. This is easy enough to see - at x=0 the curve "peaks" and is neither rising or falling. At x=1, the slope is 2 - the tangent line at x=1 is rising 2 units for every unit moved to the right. At x=-2, the slope of the tangent on the parabola is -4 - for every 4 units the line rises, it moves backwards (to the left) one unit.
What the slope of the tangent line at a point on the parabola tells us, in a more practical sense, is how fast the parabola is rising or falling at that one particular point. The same is true for other types of curves and functions as well.
The reverse of differential calculus is integral calculus. Basically if function f(x) is the derivative of the function g(x), then the integral of f(x) is g(x) (not quite, but almost). Instead of telling us the slope of a tangent line, the derivative can be used to measure the area underneath a given curve.