The Decline Effect
Pretty fascinating.
http://www.newyorker.com/reporting/2010 ... ntPage=all
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auntblabby
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it would not display on my puter. please tell me what it was about.
Can you see the print page here?
http://www.newyorker.com/reporting/2010 ... ntPage=all
It's quite a complex idea, and quite a long read.
As I understand it, it seems that you can create testable positive scientific results, but then for some reason, the positive results start tailing off.
There is an example of pharmaceuticals that start out efficacious, but then with more testing, the effectiveness starts declining, for seemingly no good reason.
Another example given is an ESP experiment that was conducted, where one man achieved one in two million results, three times in a row. But then, with later testing, his ability to recreate that result tailed off.
The Third example was a seeming correlation of symmetry of physical features in males to genetic attractiveness, which then devolved into a seeming non correlation;
It's pretty spooky. I am still processing what I think it could mean. I may share my view later
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here is a good article explaining the decline effect:
http://scienceblogs.com/insolence/2010/ ... sterio.php
edit: wrong link
Last edited by wornlight on 08 Jan 2011, 6:11 pm, edited 1 time in total.
Thank you for posting the article, Moog.
2nd generation antipsychotics (also known as neuroleptics) were touted as the improved anti-psychotic as patients experienced far less "adverse" side-effects, notably (1) Parkinson-like tremors. Indeed, most 1st generation neuroleptics needed to be accompanies by prescription drugs to control for excess dopamine (e.g. cogentin). (2) Lethargy - the sedation effect. (3) Minor side-effect of extreme dry mouth - - this may not seem like a big deal, but it becomes problematic. Just hard for the patients and can cause dental problems too. So many discontinued their treatment, with rebound of symptoms.
Then 2nd generation neuroleptics came along....but - untoward complications did occur. For instance, onset of diabetes! Patients invariably would gain weight and oftentimes a lot. Also heme disorders can occur. Over long periods, zyprexa (and related) can damage memory and cognitive functioning, irrespective of the schizophrenia.
Regression to the mean could definitely be a factor; upon the initial diagnosis, when symptoms are really dramatic, any hard-hitting treatment is going to make a big initial impact. Over time, the results aren't so shiny.
About the article you shared: What can happen, over time, is synaptic desensitization. The efficacy does decrease, over time. However, there are other variables, like you pointed out. Schizophrenic symptoms are expected to ease up over time, depending upon the individual. They also learn to better cope with their symptoms.
I am not involved in neuroleptics, but I do know. I am a PhD student (neuroscience) and there's so much yet to be discovered. In fact, just in the news is the neural imaging of schizophrenia where we can "see" and predict the onset of schizophrenia! If we can learn that, then there's a better shot at creating better drugs. Are 2nd generation neuroleptics "better?" Well, probably not. Eli Lilly (I never spell that right) suffered as malpractice suits hit from complications from 2nd generation neuroleptics. They'd have good reason to *make amends* for their new-and-improved neuroleptics. Compelling article.
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http://scienceblogs.com/insolence/2011/ ... erio_1.php
Thank you for posting that. I've given it a good going over, but really must come back with a fresher brain to completely grok this thing. I must admit that I like the 'story' that the Leher article evokes.
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http://scienceblogs.com/insolence/2011/ ... erio_1.php
Thank you for posting that. I've given it a good going over, but really must come back with a fresher brain to completely grok this thing. I must admit that I like the 'story' that the Leher article evokes.
Yes, compelling link (above). < I'm just now reading it> Anyhow, the ideas presented aren't really new and there's a myriad of ways this effect is expressed. For myself, I'm currently looking at coincidence detection. Well...stuff overlaps!
Coincidence detection:
http://en.wikipedia.org/wiki/Coincidenc ... urobiology
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The ones who say “You can’t” and “You won’t” are probably the ones scared that you will. - Unknown
http://scienceblogs.com/insolence/2011/ ... erio_1.php
Thank you for posting that. I've given it a good going over, but really must come back with a fresher brain to completely grok this thing. I must admit that I like the 'story' that the Leher article evokes.
Yes, compelling link (above). < I'm just now reading it> Anyhow, the ideas presented aren't really new and there's a myriad of ways this effect is expressed. For myself, I'm currently looking at coincidence detection. Well...stuff overlaps!
Coincidence detection:
http://en.wikipedia.org/wiki/Coincidenc ... urobiology
i posted the wrong link... this is it: http://scienceblogs.com/insolence/2010/ ... sterio.php
I actually find this rather comforting. It shows me that the innaccuracies caused by positive reporting/publication bias/confirmation bias can be corrected with repeated testing. It shows me that the scientific method is very good indeed, but that it takes many, many replications of an experiment to nullify the errors introduced by excited humans.
For many years I thought this is what had happened with Wakefield and the vaccine/autism research. I thought he had unconsciously introduced error with positive reporting. More recently it turns out that he consciously committed fraud and flat out fabricated data. Although deliberate fraud is reprehensible, I don't think there is anything dishonerable about innaccuracies caused by positive reporting/publication bias/confirmation bias. I think it's just one of those natural, human things that the scientific method eventually corrects for. It's just that this correction takes many years and many repetitions of the research. I like the name Decline Effect. But I think it's just a cute way of pointing out that experimental repetition must happen over the course of years in order to counter unconscious bias of scientists.
Unfortunately the media jumps all over research the split second it is published. They aren't about to wait 10 years for the Decline Effect to take effect. This makes sense. It's in their own best interests as media to pounce on news stories just as fast as they hear about them. It's their role. Unfortunately it does give people who are unfamiliar with the scientific process a skewed view and makes them think that the scientific process is inherently flawed because results keep changing.
Thank you also to Wornlight for the link giving the calm explanation of why this shouldn't rock anybody's world about the reliability of the scientific method.
For many years I thought this is what had happened with Wakefield and the vaccine/autism research. I thought he had unconsciously introduced error with positive reporting. More recently it turns out that he consciously committed fraud and flat out fabricated data. Although deliberate fraud is reprehensible, I don't think there is anything dishonerable about innaccuracies caused by positive reporting/publication bias/confirmation bias. I think it's just one of those natural, human things that the scientific method eventually corrects for. It's just that this correction takes many years and many repetitions of the research. I like the name Decline Effect. But I think it's just a cute way of pointing out that experimental repetition must happen over the course of years in order to counter unconscious bias of scientists.
Unfortunately the media jumps all over research the split second it is published. They aren't about to wait 10 years for the Decline Effect to take effect. This makes sense. It's in their own best interests as media to pounce on news stories just as fast as they hear about them. It's their role. Unfortunately it does give people who are unfamiliar with the scientific process a skewed view and makes them think that the scientific process is inherently flawed because results keep changing.
Thank you also to Wornlight for the link giving the calm explanation of why this shouldn't rock anybody's world about the reliability of the scientific method.
Thanks for your input Janissy. As a non sciency person, I was led to the decline effect story as meaning something other than what it does appear to be. Occam's razor seems to have put things in perspective here.
I still like the idea of a universe with an elastic reality
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Moog, that was very interesting. Thanks for sharing.
A somewhat related, older article:
"Most Science Studies Appear to Be Tainted By Sloppy Analysis"
by Robert Lee Hotz
http://online.wsj.com/article/SB118972683557627104.html

