A couple of years ago I read a New Scientist article that said some cosmologists had solved the disembodied space brain issue. The issue being that across the lifetime of an expanding universe, observers such as ourselves may eventually be outnumbered by "Boltzmann Brains", minds spontaneously formed by random chance or quantum fluctuations. This would undermine the validity of physics as seen by non-typical observers such as humans.
I forget exactly how they said the Boltzmann Brain problem had been dealt with. I just remember thinking it was a bit of a missed opportunity. There are plenty of stubborn unanswered questions in physics - maybe thinking like a disembodied space brain is the change of perspective we need to answer them?
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