I got my acrylic at home depot. I first bought some thin stuff for about 10 bucks, but you really want the heavier stuff, 0.22 inches. The thinner stuff can be cut and snapped. there should be acrylic blades sold near the sheet. Google some instructions for cutting acrylic. The sheets come with a protective cover, but you'll still want to inspect it carefully. Minor scuffs on the protective covering is fine.
For the holes I tried regular bits, but they tend to crack the acrylic. I got some glass bits(also from home depot). They were about 20 bucks for four. I use a drill press. The bigger the bit is, the more likely it will crack the acrylic. go slow. Clean the bit often.
For cutting, score and snap, as per google. Thicker can be saw cut.. a dremel or router is best. I scored my 0.22 sheet, but it was hard to snap. Wear safety glasses and gloves at all times.
For the large hole I bought a adjustable hole cutter at princess auto for 10 bucks. Adjusted out to 120 mills its waaay to fast and lightly melted the plastic. It also felt dangerous. Next time I will use a router table.