I'm always happy to skip anything with Adam Sandler in it (how his career survived
Little Nicky I will never understand), so '
Grownups' would be a
NO brainer.
I know its supposed to be Aspie subculture, but I despise Anime (except for
Astro Boy 
), so
Last Airbender since it can't be any better than its source, is out before its in.
Eclipse...
hmm..the only thing worse than a chick flick (besides Anime), is a
teen chick flick. Gag me with a spoon.
Sorcerer's Apprentice. A fantasy film with Nicholas Cage. Isn't that an Oxymoron?

Or just an actor moron?
Steve Carrell is always good for a giggle, the trailers for
Despicable Me are amusing, and Pixar almost never misses, so...
I'd say its a coin-toss between
Despicable Me and
Toy Story 3. Check the reviews and when you get there see whichever one isn't sold out. The see the other one when that lets out.

Also TLA isn't an anime but it is still a terrible film in general and will no doubt get razzies this year.