It's certainly one of my favourite American comedy shows. Not coincidentally, it was created by Bill Lawrence, who also contributed to another favourite sitcom of mine, Spin City.
I just think JD is so adorable as a protagonist. He's such a well-intentioned goofball. A bit like SpongeBob SquarePants in that respect. The entire cast is funny and very well-cast. I don't think there's a single main character I found boring. John C. McGinley does a very adequate job as Dr. Cox, really brings his A game to the show. And the janitor is just hilarious.
I caught a lot of episodes when they were re-airing it on the Dutch version of Comedy Central last year, mostly episodes from seasons 7 and up, but sometimes also some early stuff. It never gets tired for me.
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clarity of thought before rashness of action