I'm in agreement with everyone else, so far - an antagonist supplies opposition to the protagonist for whatever reason, but the villain does it for purposely malignant reasons.
Case in point - in The Fugitive, Tommy Lee Jones plays the antagonist trying to recapture framed Harrison Ford, not because he's a bad person, but catching Harrison Ford is just his job.
While a genuine villain would be someone like Darth Sidious/Emperor Palpatine of the Star Wars saga, who wishes to plunge the whole galaxy into a thousand years of darkness under Sith rule by drawing Anakin Skywalker into a Faustian deal, in which he loses his humanity both spiritually and physically when he became Darth Vader, then tries the same with Anakin's son, Luke.
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-Bill, otherwise known as Kraichgauer