LOST - I loved this show until they killed off my favorite character (Charlie Pace). Now I don't care anymore, although John Locke is still one of the single coolest characters in the history of broadcast television.
Friends - I've only watched three episodes of this show, and none of them answered my questions to why this was such an all conquering phenomenon
Heroes - I started watching this when LOST killed the aforementioned burnt-out rock star/sympathetic recovering junkie character I liked. The entire second season is one big middle finger to its fans.
NCIS - OK, I love this show, alot, but I have no clue why every elderly person on the planet likes it.
Family Guy - There's some built-in like for me, because it's set in my home state, it was created by a local, and frequently name checks local places, people and saying and I like surreal humor, but the Peter/Chicken thing was only funny the first time it randomly interrupted the plot. Then it just got boring. Now the show is run is manatees and the new episodes don't stand up to its original run.
The Simpsons since approximately Season 14 - with a couple exceptions (namely "Homer Simpson, This Is Your Wife", which Ricky Gervais wrote, and the Emmy-winning "Eternal Moonshine of the Simpson Mind") this show has just become a shell of it's once great self. They ran out of ideas after season 14, the last season with multiple above average-to-excellent episodes, and the last to make good use of celebrity cameos (namely those of David Byrne and George Plimpton). I mean, last season, Zooey Deschanel - one of the most talented character actresses in Hollywood - guest starred in an episode and even she couldn't save that episode's plot. I'd really love for this show to end before it starts getting embarrassing to even like the older episodes.
The Grizzly Man Diaries *SPOILER* He gets eaten by bears.
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here be dragons