When I am in my depressed mood I feel this way.But when I was manicly depressed from ages 8-14,I hated myself,I self-esteem wasn't really high(and in some ways it still is),I of course was REALLY depressed,I felt hopeless and useless,although I tried my best to be nice to others.(Today being nice to thoer people really isn't THAT much of a problem but I only take crap off people for so long).I felt like everything bad that happened to me was my fault and in a way I still do.Things are ALOT different in my mania mood though.
-SpaceCase 
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Live and let live.