Article in WSJ on immune system + whipworms for autism

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PaintingDiva
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14 Feb 2012, 11:16 am

FYI, interesting theory/experiment and it sounds like it is working a bit for this one man's son. Link at bottom of article:

Quote:
Some bugs are good for our health, and a pig parasite called the whipworm appears to be one of them.

Whipworm eggs have been found in human studies to reduce symptoms in a host of diseases that affect the immune system. Researchers at several universities have shown promising results in small numbers of patients with multiple sclerosis, Crohn's disease and ulcerative colitis. Biotechnology companies are conducting large clinical trials of the treatment. Other studies targeting rheumatoid arthritis, autism and some allergies are expected to begin this year.

Many scientists think that autoimmune diseases are on the rise because humans aren't being exposed to the same bugs that we used to have contact with. One potential new treatment uses the eggs of a pig parasite. Shirley Wang explains on Lunch Break.

Scientists have been trying to figure out why diseases that affect the immune system have increased dramatically over the past several decades in much of the developed world. For example, the incidence of asthma in U.S. children under 17 was up 28% in 2009 from 1999, according to government data.

The whipworm treatment was born from a theory known as the hygiene hypothesis, which essentially says our environment has become too clean. Humans aren't exposed to microorganisms in the environment as much as they used to be, when more people farmed or lived closely with animals.

While many diseases have diminished thanks to improved hygiene and medicine, people aren't exposed to bacteria that helped regulate the immune system, the theory goes. This lack of exposure may, in part, be responsible for the increase in diseases in which the body's immune system goes awry.

Based on this hygiene hypothesis, researchers at the University of Iowa wanted to find a safe parasite—one that wasn't known to cause infection or illness in humans—for therapeutic purposes. This type of treatment is known as helminthic treatment, or more specifically TSO, from the Latin name for whipworm eggs: Trichuris Suis Ova.

"It looks like the helminth [the parasite] rebalances the immune system," says Bobby Sandage, chief executive of Burlington, Mass.-based Coronado Biosciences, which is finishing up an early-stage clinical trial of whipworm to treat Crohn's disease. A Phase 2 trial is planned for this year.

In many autoimmune diseases, immune cells known as T1 cell cytokines proliferate and fight against the body's cells, the way they do when the body detects foreign invaders.
A Beneficial Bug?

Clinical trials using whipworm therapy have been run or are planned for the following conditions:

Crohn's disease
Ulcerative colitis
Multiple sclerosis

Rheumatoid arthritis
Psoriatic arthritis
Autism

Tree nut allergy
Seasonal allergy (hay fever)



Patients and study participants consume microscopic whipworm eggs, above left, which hatch into worms, right, in the intestines. The worms appear to spur a beneficial immune-system reaction.

The introduction of the whipworm appears to spur the body to produce more of a different type of helpful immune cell—T2 helper cytokines—as a defense against the worms. This separate immune response appears to help counter the inflammatory response from diseases, say researchers.

This approach differs from many available treatments on the market for inflammatory diseases. If these drugs, which tend to suppress the immune system, are given in doses that are too high, the immune system can be compromised, says Robert Summers, a professor in gastroenterology and hepatology at the University of Iowa who helped run the trials.

TSO treatment is likely to be much less hazardous because it doesn't directly attack the body's immune system, says Dr. Summers.

When it comes to using bugs as treatment, one key, of course, is finding ones that won't sicken people.

Whipworm from pigs appeared to be a good candidate because they don't naturally infect humans and can't reproduce in them. Once the eggs are ingested, they pass through the stomach to the intestine. There, the worms hatch and latch on, and apparently prompt the modulating effect in the immune system. After about two weeks, they die and are absorbed or excreted.

Dr. Summers and his colleagues demonstrated encouraging findings in two studies published in 2005. One examined 29 patients with Crohn's disease and found that after six months, 21 were considered remitted. (There wasn't a control group for comparison.) The other was study of 54 patients with ulcerative colitis. Patients who received TSO treatment improved significantly more than those who got placebo.

Another area of interest for TSO researchers is in multiple sclerosis, with two small studies published last year. One of these, published in the Multiple Sclerosis Journal, showed brain lesions decreased in four of five patients three months into treatment, and rebounded two months after it ended.

Some researchers say the therapy could hold promise for autism as well.

Eric Hollander, director of the Autism and Obsessive-Compulsive Spectrum Program at Montefiore Medical Center and Albert Einstein School of Medicine in the Bronx, N.Y., expects to begin recruiting for a human trial in adults with autism by the end of March.

"People are just beginning to think about modifying the immune inflammatory response to see if it has some sort of effect on behavioral symptoms," says Dr. Hollander.

In 2005, Stewart Johnson, a portfolio manager at an insurance company in New York, and his wife were at their "absolute limit" with their then 14-year-old autistic son. Mr. Johnson says he exhibited extremely disruptive behaviors, and agitation. The Johnsons were close to putting their son in a residential facility.

Around this time their son made his yearly trip to summer camp—always a difficult time.

But one day, says Mr. Johnson, a camp counselor called, saying his son was calm and behaving better than he had ever seen. The night after Mr. Johnson picked up his son—finding he was indeed well-behaved—he saw his son's legs were covered with many bites from chiggers, the larvae of mites. After about 10 days, the disruptive behaviors returned. "I said, 'this can't be coincidence,'" says Mr. Johnson.

He started doing research, heard theories that the immune system may play a role in autism, and came across the work on whipworm eggs and Crohn's disease. He was able to obtain a supply to test on his son, though first he took the ova himself to make sure they were safe. The eggs, which aren't yet available in the U.S., cost €300 ($396) for a two-week vial, Mr. Johnson says.

After a reduced dosage of the invisible, tasteless eggs failed to help, Mr. Johnson consulted with the supplier, OvaMed GmbH, of Barsbüttel, Germany, and bumped up the dosage. In about 10 weeks, the disruptive behaviors ceased.

The younger Mr. Johnson, who declined to comment, lives at home and has been taking the eggs ever since. The worst symptoms don't return so long as he stays on the treatment, Mr. Johnson says.

Write to Shirley S. Wang at [email protected]



wsj.com



questor
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14 Feb 2015, 12:20 pm

Thanks for a very interesting article. I've come across stuff like this once or twice before. I am interested in anything that will help.


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16 Feb 2015, 6:37 pm

Interesting...there is a history of inflammatory and auto-immune issues in my extended family. Would be awesome if something so simple could be beneficial.


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16 Feb 2015, 6:56 pm

The main harm with "way out" or experimental treatment is that people neglect the more tried and true.

One theory is that we need our worms during infancy and childhood to initially set the immune system at a more moderate response. And getting worms at a certain point of adulthood is not really going to help that much.

One study of Crohn's patients found that worms seemed to help some patients but not others.

============

and even if one sensory issues can be improved, and even if my energy can be improved so I can focus more broadly on social issues for a longer period of time,

I still want to be appreciated for the human being I am right now, not some theoretical human being I might be

And I do want to be able to pursue my pursuits of writing, activism, school, business plans . . . and including stimming at times without being made to feel bad about it.

Sensory issues are more the problem. Stimming is part of the solution.



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16 Feb 2015, 7:14 pm

AardvarkGoodSwimmer wrote:

One study of Crohn's patients found that worms seemed to help some patients but not others


It's still awesome for the ones it helped! :wink:

And, the main harm in sticking only with the tried and true is that people may avoid a treatment that is "way out" by today's standards, but may actually be more effective, no?


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Adamantium
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18 Feb 2015, 8:36 pm

A bit dated, now--but the NY Times had a good write up of the background to this back in 2012:
http://www.nytimes.com/2012/08/26/opini ... d=all&_r=0



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18 Feb 2015, 8:39 pm

Great. First you want us to eat feces and now you want to infect us with parasites. Where will it end, I wonder.



Adamantium
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19 Feb 2015, 12:08 am

ominous wrote:
Great. First you want us to eat feces and now you want to infect us with parasites. Where will it end, I wonder.

The general idea is that these parasites were part of the environment humans evolved in. They adapted to our immune response by releasing immunosuppressant chemicals, we adapted to that by intensifying our immune response.

In the absence of parasites, our hyper immune system is pathological, but once the mechanisms employed by the parasites to suppress our immune systems has been studied, we will be able to synthesize those chemicals and dwkivee them in a more palatable form than whipworm (like a tablet).



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19 Feb 2015, 12:00 pm

Adamantium wrote:
...we will be able to synthesize those chemicals and dwkivee them in a more palatable form than whipworm (like a tablet).


And that word should be "deliver" not sure what happened there, so I will blame it on Windows 8's on-screen keyboard...