Arizona Autism Study Benefificial bacteria Transfer

Post Reply New Topic

http://autism.asu.edu/Docs/2014/3-FMTst ... 2-2014.pdf

I would like to highly recommend any parents that have any progeny that meet the required specifications,
actively engage in the participation of this study!

My own observations and research into this area, have lead me to believe that Autism is not a matter of genetics
but of location, diet and bacterial flora

I agree that this is part of the answer for many. But the genetic component interacting with the environment is significant. People with ASD & ADHD share patterns of both immune and brain genetic alleles which are present in a large part of the population. So these are not bad genes, but the pattern with the environment/life-style create challenges. The table illustrates the interaction.

Living in an autism cluster, I have zero doubts that a strong genetic component exists. I am happy to buy into epigenetic variations (not sure if I said that right) and other factors that can affect how ASD presents- or maybe even act as triggers, but I don't think those ideas will ever be found to entirely replace genetics.

I do like the fact that the child has to have the ability to agree to participate in the study, btw.

Absolutely, a bad diet can contribute. But there are many contributors, so you would require a huge population to get statistical significance.

But what people care about is how to reduce undesirable symptoms. So what is the good diet? You will be hard-pressed to get statistical significance for "good diet" unless you shape it to counteract unknown genetic issues. So if you have an immune system strengthening diet and lifestyle combined with a dopamine and serotonin friendly diet and lifestyle (phenylalanine, tyrosine, and tryptophan), you will find a positive correlation to decreases the symptoms of ASD, but this is already known.

KariLynn wrote:

I agree that this is part of the answer for many. But the genetic component interacting with the environment is significant. People with ASD & ADHD share patterns of both immune and brain genetic alleles which are present in a large part of the population. So these are not bad genes, but the pattern with the environment/life-style create challenges. The table illustrates the interaction.

I am really looking at this from a dietary/family dietary perspective
families tend to eat the same things, so a bad diet can be a causality of of a cluster
this does not predispose a genetic causality

I'll agree that recent rapid increase of prevalence and severity of ASD is due to post WWII pollution. But not that ASD has evolved in the last couple hundred years.

ASD and other learning disabilities share in common multiple immune sensitivity genes and brain architecture genes. These genes are common in the general population so give benefit in some environments. They provide challenges in less favorable polluted environments. So maternal health and maternal and infant/child environment are very important. ASD & ADHD kids come more often from families of leaders, entrepreneurs, physicians, engineers and scientists. In ASD, 12.5% of fathers and 21.2% of the grandfathers are engineers. So the genes are inherently "good".

It is estimated that autism genes evolved in the last 250,000 years. Greater than 50% of the world population has been agricultural until the last 50 years. The Industrial Revolution started in the US in 1760. Although pollution has been a problem since the appearance of our earliest ancestors, after World War II, the type of pollution involved changed significantly. Industries began manufacturing and using synthetic materials such as plastics, polychlorinated biphenyls (PCBs), and inorganic pesticides like dichlorodiphenyl trichloroethane (DDT). These materials are not only toxic, they also accumulate in the environment—they are not biodegradable.

Noted ASD experts have performed retro-diagnosis on historic people. I trust their ability to dx ASD.

Simon Baron-Cohen(& others): Isaac Newton (1643–1727), Nikola Tesla (1856-1943), and Albert Einstein (1879–1955)

Tony Attwood: Thomas Jefferson (1743–1826), Wolfgang Amadeus Mozart (1756-1791), Albert Einstein (1879–1955), Alan Mathison Turing (1912–1954)

Oliver Sacks: Henry Cavendish (1731–1810), Thomas "Blind Tom" Wiggins (1849–1908)

http://www.abc.net.au/catalyst/gut_reaction_part_1/

http://www.abc.net.au/catalyst/stories/4070977.htm

It makes no sense to contemplate environmental factors outside of a genetic context. It makes no sense to contemplate genetic factors outside of an environmental context. It makes no sense to contemplate epigenetic mechanisms outside of both genetic and environmental factors.

To say that any one of these things is "the cause' without acknowledging the role of the others is a mistake.

If you look at the Harvard School of Public Health study showing that maternal exposure to particulate emissions in the third trimester closely correlate with increased autism rates, the effect seems to double the (still low) probability of autism in the child.

But they don't examine mechanisms or the genomes of the studied population. Would the rates be the same for all genotypes? Might additional study show that different genotypes respond differently to the same maternal environmental stresses? This seems highly likely but isn't known. Maybe for some genotypes, the probability of autism goes up 800% under these conditions and for others there is no effect. This won't be known until the work is done to get the data.

It's OK, perhaps even ethically correct, to acknowledge the limitations of current understanding.

http://www.nature.com/news/epigenome-th ... ls-1.16955

http://learn.genetics.utah.edu/content/ ... ics/intro/

Well said!! !!

While this addresses an important contributor and provides insights to reducing symptoms for some, it is one of many contributors, not a cause. ASD people are systems thinkers. A system approach is needed!! !!

If you have an hour this 2014 Congressional meeting on Autism is very insightful http://oversight.house.gov/hearing/exam ... disorders/

Note: While the APA recommends integrated teams during the hour long hearing on better collaboration, the medical lead from NIH and educational lead from Dept of Education do not speak once to each other. Also, neither have a strong interest in Autism, just doing the job given to them. Such a sad statement on national leadership on the behalf of ASD.

Dr Insel is a moron.

When a friendly panel member invites you to explain that the scientific method requires duplication of research to confirm findings, and then NOT take the opportunity to defend this truth is ridiculous.

The GAO report was a joke. This country is so great when it's good, it just makes it more terrifying to see this kind of nonsense.

I may not have a phd or any letters after my name
but I do have an iq of 120 and a peak of 140 at pattern recognition

and the thing that I would like to draw to the attention of the numerous nay sayers and self imposed experts
that have decided that this thread is a place to debate this issue is :
f**k OFF!

I didn't start this thread to debate this issue!


I started this thread because I honestly think this is the end of autism!

I REALLY,REALLY and REALLY want Arizona parents to get their children to participate in this study!

I am going to start another thread about this, so disagree about it there.

I am sorry you are upset. You touched on a very sensitive subject. People here do feel free to express their ideas and opinions. Next time make it clear you are informing, but do not want people comments that are not inline with yours.

I expressed a sincere concern, and I believe was respectful. I am an Aspie, so could be off. But this comment is definitely off.

I may not have a phd or any letters after my name
but I do have an iq of 120 and a peak of 140 at pattern recognition

and the thing that I would like to draw to the attention of the numerous nay sayers and self imposed experts
that have decided that this thread is a place to debate this issue is :
f**k OFF!

I didn't start this thread to debate this issue!


I started this thread because I honestly think this is the end of autism!

I REALLY,REALLY and REALLY want Arizona parents to get their children to participate in this study!

I am going to start another thread about this, so disagree about it there.

It is all good. As long as your breathing there is an opportunity for healing. Take care

I am Really Sorry!

There have been times when I thought I was OK with having autism, when I thought I had gone through all the stages and had reached 'acceptance',
but I have recently realised and am in the process of processing, that,
there is no escaping, healing or refuge from

being
an
emotional
cripple
!