Emergence of a Deadly Coronavirus

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kraftiekortie
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17 Mar 2020, 9:06 am

Thanks, Jimmy, for this valuable info.

Pepe
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17 Mar 2020, 9:13 am

kraftiekortie wrote:

Thanks, Jimmy, for this valuable info.

I take your point. :wink:

kraftiekortie
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17 Mar 2020, 9:28 am

Nothing wrong with kidding around---but we have to hang out and make this into a discussion which helps us get through this.

I'm a big kidder myself. I'm not a fan of "gallows" humor----but I understand the reason for it.

Imagine if this new antiviral medication actually works for us? That would really make things much better, and promote an earlier "normalcy."

magz
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17 Mar 2020, 9:36 am

jimmy m wrote:

I read an article by Josh Bloom this morning. It may be of some interest:

As the Wuhan coronavirus relentlessly engulfs the world, scientists are relentlessly looking for a way to treat the infection. A vaccine is more than a year away, but an antiviral drug called remdesivir is being evaluated in clinical trials by Gilead Science, the world's premier antiviral drug company.

Even if an effective vaccine for the Wuhan coronavirus is discovered, which is by no means a certainty, it will be at least a year (more likely two) before you'll be rolling up your sleeve. And it is by no means certain that an effective vaccine will be found at all. Despite years, in some cases decades, of research, there are still no vaccines for a number of important infections, such as HIV/AIDS, hepatitis C, norovirus, Lyme and herpes simplex.

Although it is better to prevent an infection than treat one, sometimes drugs can be so effective in treating infections that the distinction becomes nebulous. For example, HIV/AIDS was an automatic death sentence prior to 1995, but it is now so well-controlled by very potent drugs that HIV+ people lead lives that aren't very different from those without the infection. And because of a massive 25-year drug discovery campaign, hepatitis C (HCV), which has infected more than 3 million Americans, can now be cured in 95+% of the time.

We should all cross our fingers and hope that remdesivir, Gilead Science's experimental antiviral drug which is now being evaluated in multiple clinical trials in China, will work even partially as well as the AIDS and HCV drugs. If so, Gilead will have pulled off another miracle.

His final conclusion is that:

Remdesivir is a fairly potent inhibitor of coronavirus replication with no obvious toxicity. It may or may not work as a pill but this is irrelevant at this time since it will probably be given IV. In another study in rhesus monkeys, data indicated that a significant concentration of the drug will be found in the blood and that an adequate quantity of the drug should be delivered to the sites where it is needed.

Given the properties of remdesivir and the desperate need for a coronavirus therapy, I would estimate that the drug has at least a 50% chance of becoming the first drug to treat the virus.

Source: ASCH newsletter of 17 March 2020, Can Gilead's Remdesivir Tame The Coronavirus? The actual article is quite extensive and the scientific underpinnings and logic is included in the article. So you may be interested in reading the entire article.

Thanks for sharing!

And I want to remind all of us: the coronavirus is relatively harmless for most of us. We're doing all these things to avoid
1) infections in as much as possible vulnerable people (old and seriously sick)
2) overload in hospitals (I admire the Chinese for building a whole hospital in 6 days but who else can afford it?)

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Last edited by magz on 17 Mar 2020, 9:41 am, edited 1 time in total.

ASPartOfMe
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17 Mar 2020, 9:38 am

86% of people with coronavirus are walking around undetected, study says

Quote:

Stealth” coronavirus cases are fueling the pandemic, with a staggering 86% of people infected walking around undetected, a new study says.

Six of every seven cases – 86% — were not reported in China before travel restrictions were implemented, driving the spread of the virus, according to a study Monday in the journal Science.

“It’s the undocumented infections which are driving the spread of the outbreak,” said co-author Jeffrey Shaman of Columbia University Mailman School, according to GeekWire.

Using computer modeling, researchers tracked infections before and after the Chinese city of Wuhan’s travel ban.

The findings indicated that these undocumented infections with no or mild symptoms — known as “stealth” cases — were behind two-thirds of the reported patients.

“The majority of these infections are mild, with few symptoms at all,” Shaman said, Mercury News reported. “People may not recognize it. Or they think they have a cold.”

These “stealth” cases were then able to transmit the bug that could cause severe symptoms in other people, according to the researchers.

“It will continue to present a major challenge to the containment of this outbreak going forward,” Shaman said, adding that it underscores the importance of restrictions on movement in hard-hit regions.

COVID-19 has spread across the world to 182,400 people, causing at least 7,100 deaths, according to a tally from Johns Hopkins University.

NYC Mayor de Blasio ‘considering’ ordering New Yorkers to shelter in place over coronavirus

Quote:

Mayor de Blasio said Tuesday he may order New Yorkers to stay home to reduce the spread of coronavirus.
Hizzoner told CNN the city is “absolutely considering” ordering city residents to “shelter in place” like San Francisco, where people can only leave home for food, medicine and exercise for the next three weeks.

“We’re going to look at all other options, but it could get to that for sure for the whole country," de Blasio said.
“We need to have in our minds that this could be a crisis of at a minimum several months," he added. “It could take us through the summer.”

De Blasio said on PIX11 Tuesday he may also institute curfews, road restrictions and other shut downs.
“All of that is on the table right now, it’s being assessed daily and hourly,” he said. “If we take those more draconian measures, we have to do our damnedest to compensate for the human impact."

The closures could last for several months, according to de Blasio.
“I’m very, very worried about…the impact on people’s livelihoods," he said on CNN.

De Blasio added that businesses could “absolutely” be shuttered “even longer” than even April and May – with his own health commissioner predicting the outbreak may last through September.

The closures mean the federal government needs to provide “direct income replacement," de Blasio said on CNN.
“A lot of people are going to lose their jobs, I feel horrible about that," he added on PIX11.

De Blasio didn’t think a $1,000 check for every American adult, as proposed by Sen. Mitt Romney, isn’t enough for a “three to six month crisis.”

“People want to work, we’re telling them that they can’t…it’s not safe to work,” he said on CNN, acknowledging that people need to buy food, medicine and rent.

Trump touts cooperation with states on coronavirus after criticizing Democratic governors

Quote:

President Trump on Tuesday swiped at the Democratic governors of Michigan and New York even as he sought to project unity with state officials over the handling of the coronavirus.

In a pair of morning tweets, Trump targeted New York Gov. Andrew Cuomo (D) and Michigan Gov. Gretchen Whitmer (D) after both appeared on television to discuss the government response to the virus.

"Cuomo wants 'all states to be treated the same. But all states aren’t the same," Trump tweeted, chastising the New York governor for the second consecutive day. "Some are being hit hard by the Chinese Virus, some are being hit practically not at all. New York is a very big 'hotspot', West Virginia has, thus far, zero cases. Andrew, keep politics out of it

Cuomo appeared on his brother Chris Cuomo's show on CNN Monday night, and he has in recent days called on Trump to take decisive action and issue blanket guidelines to states for combating the coronavirus.

Trump then took aim at Whitmer moments after she did an interview with MSNBC, a network the president frequently criticizes.

"Failing Michigan Governor must work harder and be much more proactive. We are pushing her to get the job done," Trump tweeted. "I stand with Michigan!"

Whitmer in her interview questioned Trump urging governors to try to purchase ventilators and other medical equipment on their own, calling it "kind of mind-boggling" to ask states to "work around the federal government."

Minutes after singling out Cuomo and Whitmer, Trump tweeted that his administration "is working very well with the Governors and State officials. Good things will happen!"

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Last edited by ASPartOfMe on 17 Mar 2020, 9:56 am, edited 4 times in total.

kraftiekortie
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17 Mar 2020, 9:40 am

I hope widespread testing happens soon.

Misslizard
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17 Mar 2020, 9:41 am

Pepe wrote:

kraftiekortie wrote:

We have to be able to work with each other.

"Pigs arse!"
Not me!
I'll knock down grannies who get between me and that last roll of toilet paper! :twisted:

Not this granny you wouldn’t.Id knock you from hell to breakfast. :twisted:

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kraftiekortie
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17 Mar 2020, 9:43 am

I can't believe Lizard's a grandma. She just doesn't seem like a grandma, somehow LOL

I've never even had a kid, no less a grandkid.

Misslizard
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17 Mar 2020, 9:45 am

kraftiekortie wrote:

I can't believe Lizard's a grandma. She just doesn't seem like a grandma, somehow LOL

I've never even had a kid, no less a grandkid.

There are two of them.Seems unreal to me also.

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Fnord
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17 Mar 2020, 9:48 am

Misslizard wrote:

kraftiekortie wrote:

I can't believe Lizard's a grandma. She just doesn't seem like a grandma, somehow. I've never even had a kid, no less a grandkid.

There are two of them.Seems unreal to me also.

You're still young enough to have fun with them and to spoil them rotten!

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Misslizard
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17 Mar 2020, 9:55 am

Fnord wrote:

Misslizard wrote:

kraftiekortie wrote:

I can't believe Lizard's a grandma. She just doesn't seem like a grandma, somehow. I've never even had a kid, no less a grandkid.

There are two of them.Seems unreal to me also.

You're young enough to have fun with them and to spoil them rotten!

I have no idea how to play with them.lol I did parallel play when I was a kid.They sure make a lot of noise.Right now I’m avoiding all children since they usually are chock full of viruses.I’d be tempted to spray them down with Lysol.Their mom might get mad about that.

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magz
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17 Mar 2020, 9:57 am

Misslizard wrote:

Right now I’m avoiding all children since they usually are chock full of viruses.

That's actually very reasonable of you.

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jimmy m
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17 Mar 2020, 9:59 am

One of the steps I took in preparation for the coronavirus pandemic was to buy a very special air cleaner that incorporates far ultraviolet light (UV-C) to kill viruses including coronavirus free floating in the air. I have been using it for a couple weeks now and reported my observations two days ago.

1. The unit is eliminating free floating particles from the air. I had asthma for most of my life and have a high sensitivity. I have observed the air is dramatically cleaner.
......
4. The air coming out of the unit had a freshness and crispness to it. Sort of like the air you get in the middle of winter after a fresh snowfall. Not exactly the same but close.
5. So I have found that I was able to get a better nights sleep with the unit. It is reducing the free floating particles from the air. It made the air purer so I could breath better during the night. It makes it easier to breath.

I rolled this over in my mind wondering if I could quantify it. I thought many months ago I had done a sleep analysis using a fitbit and reported that out in a different thread. So it might be possible to quantify. So I began wearing my fitbit. This is what I observed:

Last night my I had 1 hour and 10 minutes of REM sleep and 1 hour and 31 minutes of Deep sleep. Those are really good numbers for a 71 year old-timer.

Then I noticed the fitbit added a new screen. It was titled "Estimated Oxygen Variation". The new graphic indicated "Blood oxygen saturation normally fluctuates, but high variations can be linked to breathing issues. Estimated oxygen variations approximates the changes in your blood oxygen saturation."

In looking over my graphics from last night, it was low during the entire night. This indicated that my blood oxygen saturations were good, that I did not experience any issues along the line of sleep apnea. So from my perspective it displayed the effect of the freshness and crispness of the air on producing a good nights sleep.

Sleep (especially REM and Deep sleep) is one of the ways our bodies repair themselves. It is an integral part of our immune system. IMHO peaking the performance of your immune system is another benefit to dealing with the threat of the coronavirus.

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magz
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17 Mar 2020, 10:01 am

^ Just leave the room when UVC source is on, otherwise you risk very bad burns.
And yes, sleep sufficiently, it's the safest and surest way to help your immunological system deal with any threat.

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ASPartOfMe
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17 Mar 2020, 10:06 am

Times Square cam

KRON San Francisco Cams

Hollywood Boulevard Cam

Misslizard
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17 Mar 2020, 10:12 am

magz wrote:

Misslizard wrote:

Right now I’m avoiding all children since they usually are chock full of viruses.

That's actually very reasonable of you.

What if all the grownups die from this and just the children are left...
Star Trek episode comes to mind.

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