For me, it depends on the situation.
For example, if I'm in my room listening to my stereo or whatnot, and a friend of mine calls and asks me if I want to hang out at the mall with him or her, then I actually won't mind having my routine disrupted, whereas if the place I work at calls me in, then I might have a little mini-meltdown.
Also, when I was in grades 11-12, and my sister asked me to play with her while I was in the middle of listening to my stereo, I would tell her to go away, and then Mom would try to help us come up with a compromise (thank god she did not take sides!).
But if I have to change my routine at the last minute to, say, go bowling with a friend, or hang out at the mall, then, sure, it's worth it.