There is little that can be done about being autistic other than certain medications and therapy, it is with us to stay. However physical Ugliness and Beauty are perceptions that are amplified and reinforced by how you feel. If you feel beautiful projecting confidence people will notice. If you feel ugly and project that outwardly that too is amplified and reinforced. Same goes for saying that "Nobody wants me", That is totally not true. You just haven't met that person yet. Do not despair, love and companionship are out there for you.
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The impossible is only something that hasn't been done yet.