One of the keys to writing is the maxim "Show, don't tell".
It is far more interesting to read what a sad character says, does, and looks like than to simply read the words, "She was sad".
In fact, don't even use the word "sad" (or any synonyms) to describe the character; keep it all about active descriptions without going overboard.
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The mere fact that science may not yet adequately explain an object, event, or experience does not mean the immediate explanation should automatically default to a conspiratorial, extraterrestrial, paranormal, or supernatural cause.