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Over 1,000 genes implicated in autism

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Marybird
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29 Jan 2020, 11:46 pm

Genetic Causes and Modifiers of Autism Spectrum Disorder

https://www.frontiersin.org/articles/10 ... /full#B199



carlos55
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30 Jan 2020, 4:51 am

I suspect some genes are more important than others and editing one has a cascading effect on others.

Also there is the often neglected RNA that has only recently been found to have a role in autism. Science is only now looking at RNA.

Basically wont be easy but not impossible either within a decade or two i think they will have cracked it.

They will need to distinguish between natural human difference and disability also in their work.


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Karamazov
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30 Jan 2020, 6:14 am

From firemonkey’s article linked in first post wrote:
Alfredo Brusco of the Città della Salute Hospital. "the majority of these heterogeneous diseases are probably associated with various variants in genes that are important for neurological development, and which become pathologies when combined together".


Sounds to me like they’re conceptualising autism to arise from a genetic base analogous to, but vastly more complex than, sickle-cell anaemia.
That is to say there are many NT’s with ‘autistic’ genes, insufficient to manifest ASD, and that these genes may, in non-autistism causing combinations be crucial for the development the range and scope of human intellectual abilities across the species as a whole.
Which would make it possible that every human on earth could carry one or more autism associated genetic alleles, but without autism being the default neurology of the species.