I think maybe lying is something that might not come naturally for aspies, but that it can be learned, just like other social behaviours: you have to think about it, maybe prepare in advance depending on the situation, and it can be draining and/or feel uncomfortable, but the concept itself isn't incomprehensible (not like in The Invention of Lying, where he can say an obvious falsehood, and everyone just believes him because there's just no concept of a lie). And different people might have easier or harder times with various levels of lying (white lie, etc.).
You could answer "How's it going today?" with complete honesty about how crappy today was and how waking up ten minutes later than normal threw your entire day off and it snowballed and now you're on the edge of a meltdown and one more push will throw you over that edge... or you could just answer "Fine", because you know that's what they want to hear and they'll leave you alone (assuming that's what you want), even if it makes you feel guilty not telling the truth.