I am a slob by nature, but messy, disorganized spaces make it hard for me to concentrate. I have learned some habits that help me keep my house neat, although it will never make Better Homes and Gardens.
Mostly I have learned to do some cleaning tasks on a regular basis. Wash the dishes every morning (and sometimes after dinner if it's making the house reek). I also do a basic, overall cleaning of the house every Saturday morning that takes a bit over an hour. I'd prefer to use the time to do other things, but I feel so much better when the house is clean that I'm willing to "waste" the time.
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Never let the weeds get higher than the garden,
Always keep a sapphire in your mind.
(Tom Waits "Get Behind the Mule")