Unheard and impressive theory of autism

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Fern
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05 Feb 2019, 8:12 am

In science we call this a just-so story. It is very specific in defining what is going on and it sounds appealing in its simplicity of explanation, but a lot of things have to be checked before we know whether this is actually what is happening. This is not my field, but checking out the author's researchgate profile led me to a statement about this book chapter that gave me pause:

Quote:
This contains an improved-updated presentation of a peer-reviewed paper published in 1993. The updated presentation includes updating-improvement of the title. This file is Chapter 7 of my book Experts Catastrophe, and that chapter contains the presentationally-updated (otherwise unrevised) 1993 paper plus some other content relating to it. It is recommended to read this updated presentation rather than only the 1993-published version (which is not incorrect but does rather show its age in various respects and will confuse modern readers). The 1993 original was "peer-reviewed"; the updated presentation hasn't been, but is not a big deal.


I think admitting that it's not peer reviewed is a nice gesture. Books are not usually peer reviewed anyway, so yeah, nothing surprising here. Still, the idea that a unifying hypothesis not published about since 1993 can just be "updated" without peer review is a little harder to swallow.

So just to be clear, this hypothesis hasn't been peer reviewed since the advent of genomics, or even modern genetics for that matter. -and by modern, I mean we didn't even really have PCR back then. We were still cloning genes of interest using bacterial colonies (so sample sizes were exponentially smaller). This doesn't mean it's wrong, it just means it's far from consensus. It's one learned person's idea of how it works. I encourage you to read this text because I think this idea sounds nice, but keep this in mind.



Samanto Hermes
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05 Feb 2019, 8:15 am

magz wrote:
Samanto Hermes wrote:
kraftiekortie wrote:
There's an article about this published in 1993. I wish there were some reviews of it. I haven't seen any.

Science is all about collaboration and peer-review.

There are evidences supporting that: http://pseudoexpertise.com/about.php

This site openly defies scientific peer-review practice instead of giving it.

But his paper of "antiinnatia" was published in a peer-review journal.



kraftiekortie
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05 Feb 2019, 8:23 am

I don’t see the term “antiinnatia” anywhere else but in that article.

What is the origin of this term?



magz
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05 Feb 2019, 8:28 am

Samanto Hermes wrote:
magz wrote:
Samanto Hermes wrote:
kraftiekortie wrote:
There's an article about this published in 1993. I wish there were some reviews of it. I haven't seen any.

Science is all about collaboration and peer-review.

There are evidences supporting that: http://pseudoexpertise.com/about.php

This site openly defies scientific peer-review practice instead of giving it.

But his paper of "antiinnatia" was published in a peer-review journal.

Yes. In 1993. As Fern pointed out, it was before all the boom in genetic research that happened in 2000s.
I don't claim the author is wrong - but it would require a lot more work to develop the idea before we call it scientific. It would be indeed very interesting to identify actual molecular mechanisms that work as "antiinnatia" - if they exist. Or, not any less interesting, to find out they don't exist. Just like all the particle physicists were excited to find the Higgs boson of the properties predicted by Standard Model - but they were also ready to accept finding nothing in the range. They needed LHC to find out. And this concept would also need a lot of lab research to find out.


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IsabellaLinton
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05 Feb 2019, 8:30 am

I'd like to read the article but it's bothering my eyes the way it's formatted (stroke / double vision). If anyone could summarise it in a few key points I'd be much appreciative. Otherwise I'll just infer from the comments. Thanks!


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kraftiekortie
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05 Feb 2019, 8:32 am

If I can see evidence that anybody read the article..any review either positive or negative, I would feel a little better.



Samanto Hermes
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05 Feb 2019, 8:56 am

kraftiekortie wrote:
If I can see evidence that anybody read the article..any review either positive or negative, I would feel a little better.

http://scholar.google.com/scholar?um=1& ... 2486097503

http://www.autismcauses.info/2008/06/ju ... s.html?m=1

https://corticalchauvinism.com/2016/07/ ... ment-16136



Last edited by Samanto Hermes on 05 Feb 2019, 9:10 am, edited 2 times in total.

Samanto Hermes
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05 Feb 2019, 8:59 am

IsabellaLinton wrote:
I'd like to read the article but it's bothering my eyes the way it's formatted (stroke / double vision). If anyone could summarise it in a few key points I'd be much appreciative. Otherwise I'll just infer from the comments. Thanks!

You can also read here: https://auttheo.blogspot.com/2015/01/auttheo.html?m=1



Samanto Hermes
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05 Feb 2019, 9:41 am

magz wrote:
Samanto Hermes wrote:
magz wrote:
Samanto Hermes wrote:
kraftiekortie wrote:
There's an article about this published in 1993. I wish there were some reviews of it. I haven't seen any.

Science is all about collaboration and peer-review.

There are evidences supporting that: http://pseudoexpertise.com/about.php

This site openly defies scientific peer-review practice instead of giving it.

But his paper of "antiinnatia" was published in a peer-review journal.

Yes. In 1993. As Fern pointed out, it was before all the boom in genetic research that happened in 2000s.
I don't claim the author is wrong - but it would require a lot more work to develop the idea before we call it scientific. It would be indeed very interesting to identify actual molecular mechanisms that work as "antiinnatia" - if they exist. Or, not any less interesting, to find out they don't exist. Just like all the particle physicists were excited to find the Higgs boson of the properties predicted by Standard Model - but they were also ready to accept finding nothing in the range. They needed LHC to find out. And this concept would also need a lot of lab research to find out.

Quote:
(viii) autism-related genes being mainly about general regulation of gene-expression (Casanova et al, 2016),
(viii) and indeed causing reduction of gene-expression (MECP2);

Also, you should read the topic "causes and correlates of autism".



gingerpickles
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05 Feb 2019, 12:04 pm

One word: Phhhffft!

Too old, not reviewed nor have any blind studies, even if simply a butt-ton of "surveys" .

Modern genetics have already peeled 3 former ASD type disorders as actual verifiable mutation effects; even as this last decade had the Psychology fields lump so many together as "A S D" officially for the testing.

I am interested in my youngest son's rather different form than mine since no real pinpoint tested as yet, but he and his father both have ring 14 damage (extra material). My theory is that humans misuse of chemistry and pollution have reached a point that we are disturbing our genetics and ASDs are the "hiccups" caused by these various small mutations that are likely all in common locations. Autistic disorders started in in industrialized nations first after all. And are now spreading in the population. Not gonna make no paper over it. I'm lazy. Nor do I need validation. ^_^ it is just MY theory. I'll call it Hereditary permiceo exponentialiumia. HPE. Sounds legit....

And this "antiinnatia " coinage. Hoorya! he looked up a wonderful important sounding latin word for "since Birth" tacked "ia" to make a disorder! and add "anti" suffix to it in a way that will make him arrested for grammar crime! -_- (serious does anyone know of any latin babble word starting with "i" that would have anti tacked on without a hyphen? or even ancient latin word?) 0_0 Well.. I can do that.
So what if he made his own peer-reviewed PAPER. Not a full body of research. Heck Peer review. What kind of peers? what was the position in 1993? I can go to Evergreen State and have my Peers review my final thesis for graduation. In fact even the grading there is peer-reviewed. That is why the diplomas don't even carry weight to upgrade an army rank ! LOL!
Nor is it proof that all these peers signed on. Review is not = approval or accolades! In fact, no Peers expanded or touched this theory. A big flag right there.

Even junk science beats no science. The font was awful. Granted, I could not chew all the drivel so much is undigested, maybe I missed something impressive? Soon as I saw no real research I stopped bothering.
As an Opinion it can hold my interest for a moment. call it science and I will forget it faster than a ferret.

Personally, you can color me not impressed.


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gingerpickles
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05 Feb 2019, 12:11 pm

Samanto Hermes wrote:
kraftiekortie wrote:
If I can see evidence that anybody read the article..any review either positive or negative, I would feel a little better.

http://scholar.google.com/scholar?um=1& ... 2486097503

http://www.autismcauses.info/2008/06/ju ... s.html?m=1

https://corticalchauvinism.com/2016/07/ ... ment-16136


all of those loop back to himself <_<. I laugh at the sarcasm of "-Robin's Mom" comment.
I think Kraftie wants what I do, a peer expanding or debating his theory. Even better a person higher in the field directly quoting his "innate whatsit" term as an "interesting thing" they saw


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kraftiekortie
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05 Feb 2019, 6:10 pm

It has been proven, in many peer-reviewed studies, that autism has MANY causes. I believe they have isolated multiple genes which have been proven to cause autism.

One mode of treatment might be perfect for one person; but might be disastrous for another person.



IsabellaLinton
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05 Feb 2019, 6:14 pm

kraftiekortie wrote:
It has been proven, in many peer-reviewed studies, that autism has MANY causes. I believe they have isolated multiple genes which have been proven to cause autism.

One mode of treatment might be perfect for one person; but might be disastrous for another person.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135479/

I know there are many causes but I find the link to cerebellar damage (in utero or at birth) interesting. I learned about this link when I had my cerebellar stroke in 2015. I was certainly autistic from birth and prior to my stroke, but the stroke did intensify some of the characteristics described in medical literature.


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Last edited by IsabellaLinton on 05 Feb 2019, 6:15 pm, edited 1 time in total.

kraftiekortie
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05 Feb 2019, 6:15 pm

Absolutely no doubt about what you say. Autism is a very neurological condition.

I knew a kid who was severely autistic primarily because of a lack of oxygen to the brain at birth (anoxia).



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05 Feb 2019, 7:50 pm

kraftiekortie wrote:
How would one account for the folks with autism who have to wear helmets in order for them not to hit their heads on walls?

What sort of environment would be conducive to preventing this manifestation from happening?



Hitting heads on walls is generally the outcome of sensory over stimulation, right? This is talking about autistic traits being a reversion to what we evolved from. So, imagine you lived in a world of nature and only in a small tribe of people who need each other for survival. No fluorescent lights, no chemicals, no machinery, no blasting stereos, no artificial food, no engineered fabric. Alertness needed for snakes and bears, but generally predictable nature. Maybe social structure but no energy for mind games or extreme social expectations because the focus is on finding food and shelter.

I am very grounded when camping and away from technology. I don't have the survival knowledge or skills to actually live in nature, but I would if I did.



kraftiekortie
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05 Feb 2019, 8:16 pm

I like Nature. I like camping, too.