Yes I've fairly often talked to strangers. It's considered quite normal in rural Arkansas, more so than in the UK cities I've lived in, though even there it's not particularly abnormal. It's called being friendly, and I somewhat prefer it to silence because without breaking the ice a bit people tend to seem more like obstacles and potential threats to me. I usually try keep the conversation short on my side, and I don't very often start it. I've been known to open with "Hi" or "good to meet you" to the passenger in the next seat when I sit down on a transatlantic plane. Their response gives me some idea whether or not they're going to be nice, and it makes them seem a bit more human. It's rare that we say much more to each other unless they keep showing willing, and I'm careful not to be invasive. I'm also averse to getting stuck with a chatterbox. I've read that conversations with fellow-travellers are in a special category - closed-ended - and that they can sometimes be more profound and socially intimate than they would be if the participants expected to see each other again. I guess you can speak more freely because they're unlikely to be able to use the information against you.
While in Cornwall as a young teenager, I was surprised that the locals would say "good morning / afternoon / night" as they passed me. I loved it and enjoyed taking up the practice myself. I've always liked it when people are friendly. I gather people are more friendly in rural areas because traditionally they've had to have more social cohesion to survive.
I had a fascinating conversation on a train with a guy who said he'd been in the SAS. Even now when I've become more suspicious of the tendency of people to big up their reputations by exaggerations and downright lies, certain things he said make me think he was telling the truth.
So all in all I'm in favour of talking to strangers, though it depends where you are and who it is.