nanotechnology
I agree with the others who've said (essentially) that "god mode" wouldn't become boring in real life. Making the assumption that nanotechnology would put us in "god mode" to begin with, there is still plenty to do in the universe, and while we might eventually exhaust all imaginable possibilities, what is the alternative? To consciously avoid nanotechnology (and all other future enhancements)? Aside from the impossibility of that (you'll never get the entire human race to agree to it), it's a lot like not reading the last chapter of a book because then you'd finish the book. Sure, you never get to the end and you've always got some book left to read, but since you'll never read it, you're in an equivalent state, only without the benefit of the last chapter of the book. So (IMHO) you're worse off.
Human creativity, like evolution, has no "purpose." It just continues on and on. Some mutations (discoveries) lead to productive results that continue, some don't. Some have destructive side effects. But the drive to explore and create and discover is innate, and it can't be turned off, and I think that's a good thing.
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