Why do we believe autism is "hard-wired"?

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Callista
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15 Jul 2009, 10:47 am

"Cognitive differences present from birth" strongly suggests inherited neurological condition, but "differences beginning later on" does not rule it out. There are quite a few inherited neurological conditions that present symptoms quite a long time after birth.

Autism affects brain development. Not a surprise; your DNA affects how you develop, after all, not just where you are at birth. "Neurodevelopmental" is another way to describe that. Autism will almost always be different at 2 years, 4 years, 14 years, 40 years of age... I would be very surprised if it weren't.


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Prof_Pretorius
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15 Jul 2009, 11:19 am

Callista wrote:
Plasticity only goes so far, especially past age two or so. That's why they're preaching early intervention. It's easier to learn a skill like speech if you learn it early--presuming, of course, that you are ready to learn it when it's taught.

Autistic and non-autistic brains are different--on brain scans and even in their macroscopic dimensions. There are physical differences in brain-stem size, for example, suggesting different processing of sensory information at a very fundamental level.

It is overwhelmingly more common to "grow out of" childhood autistic traits than not, so I'd assume that just like it is normal for NT children to learn and grow, it is also common for autistic children.


Plasticity does not only go so far ...
Physical differences can be overcome.
If Autistic children grow out of certain traits, then you're arguing FOR plasticity.


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15 Jul 2009, 11:22 am

Callista wrote:
"Cognitive differences present from birth" strongly suggests inherited neurological condition, but "differences beginning later on" does not rule it out. There are quite a few inherited neurological conditions that present symptoms quite a long time after birth.

Autism affects brain development. Not a surprise; your DNA affects how you develop, after all, not just where you are at birth. "Neurodevelopmental" is another way to describe that. Autism will almost always be different at 2 years, 4 years, 14 years, 40 years of age... I would be very surprised if it weren't.

I think we're in agreement and merely splitting hairs.

The statement I take issue with is this one:
b9 wrote:
people with clinically significant autism will be noticed to be different even at 1 month old.

The key here is "noticed to be different." In many cases that may be the case, and in many cases it won't.

I think with current technology it's impossible to know if we really are "hard-wired" from birth with autism, or if we are pre-disposed (i.e. DNA) to develop our brains in an autistic sort of architecture.


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Crassus
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15 Jul 2009, 2:48 pm

The thing you are missing for all your harping on neuroplasticity is that autistic neuroplasticity has been demonstrated to be different from NT neuroplasticity via brain scans. Did you read the study I linked in my first post? That is what they are talking about when they talk about that "second-wave changes" thing. If the only autistic traits you have is some form of this difference, a common presentation is schizotypic traits. The present from birth autistic stuff is in the white matter white area outer edges of the brain being larger and in the central areas related to perceptions being the same relative size but in a different absolute configuration. It is in the increased rate of neuronal developments and changes in an autistic mind and decreased rate of physio-moto development. The second-wave stuff is the mechanism by which an autistic trait neuronal pruning process happens in grey matter as opposed to the NT method of neuronal pruning.

Why are so many autistic trait individuals "outside the box thinkers"? Because of the way in which their neuroplasticity presents, they never "grow up" and "lock in" in the same fashion that a neurotypical person does. Normal people reach an "adult" stage where they have the major groundwork for how they think laid down and it takes much more effort for them to rework their brain, they are past the developmental learning stage and have "locked in" on assuming that the way they have been taught to react to things is pretty much "the right way" they will neural prune and intake information and process it in a "mature" fashion with more self confidence than a "developing" brain that is "still figuring out the rules".

An Autistic brains different starting point and different mechanisms of growth cause a different growth curve. They take a few more years to figure out "how to verbalize" maybe, but once they are verbilizing they verbalize beyond the normal ability. They take longer to understand how to process emotional cues, but once they do they process far more emotional information than the normal person. Neurotypical brains reach physical maturity some time around age 25. Autistic brains reach it quite a bit later if they ever do. Sixty year autistic growth pattern brains have been shown to still be undergoing growth and plasticity shifts at a rate associated with childhood development.

Low Functioning or High functioning isn't the important difference here, an autistic brain in other ways can happen to not have the neverending growth pattern, and the neverending growth pattern could be the only autistic trait that ever physiologically presents.

These things are "hard-wired' in that they are differences in the neuronal wiring of the brain, in the genetic structure of the DNA, in the underlying physiological aspects of the human form, those parts we generally refer to as "the hard-wiring" which is actually anything but hard-wired in the sense that the wiring is laid out and never changes. It is in the different operations and mechanisms of the way the wiring is plastic. It is in the different operations and mechanisms of the very nature of their human hard wiring, up and down the system.

Do you want the full fledged run down from start to finish of how this all inter relates and works? I can explain a lot of it one baby step at a time, but most people get bogged down by the fully realized understanding of any little aspect of it. Most people are small picture types, this is a good thing, it is how s**t actually gets done. This is not me. I'm the big picture guy. I'm the guy corporate america calls "The Fixer". I'm the Super Consultant. Powerful and Important men and women by the standard of american materialist culture, the head honchos at businesses, decide they think their company is trapped in a box. In order to maximize growth they need a new way of looking at things. So they call me or somebody like me in to take in the big picture of how they fit into the society they are in and identify methods by which they can maximize the realization of the goals they state to me they have.

I walk in, take a look at "the box" and ask a few questions, and use the information they give to me to explain the options they have available and ask them which one they prefer based on the pros and cons I lay out. Then I explain methodologies by which to pursue those options and the pros and cons of them. They take what truths they can understand from my vision, and implement them as best they can, creating a new "box" that is bigger and "outside" of "the box" that they were trapped inside before. Then I go on my merry way to fix something else for somebody else. To wait for somebody else to ask me to find them a bigger box.

I get s**t wrong. Garbage In, Garbage Out. I'm just a humanform computator. I'm a Mentat. I'm a Shaman. Modern Man has forgotten to give respect to the useful function I perform. I think and experience in metaphor, have respect of the services I can provide humanity and accept them in the spirit they are given. Don't trust what I say, trust that there is something real and true that is causing me to say it. Believe in the power of metaphorical science and creative mythology to describe Truths in a different way than fully realized empirical scientific understanding.

I'm not trying to promote some new age superstitious belief. Anything but. I'm as sceptical as they come, I don't believe anything without a rational argument supporting it. But just because it doesn't fit into your box doesn't mean it is irrational. It means that if my rational argument obeys logic and the principle of parsimony, you need to find a bigger box and stop hiding from the truth. Instead of waiting for the geniuses to force everybody else to accept the newer bigger boxes one at a time, just accept that there will always be a bigger box. Our understanding of anything will ALWAYS be incomplete, for if we had a complete understanding we would have reached the end of the Universe. Reality would be a complete contained defined system that has no more new information to generate. The lack of Genesis of Information is Death. If the Universe and all reality is not growing and changing, then it is Dying. Our Universe has to be expanding because otherwise it would be shrinking.

Take this as you will. I've never been one to hide from the fact that I'm often called delusional. I only ask the question "okay, if I'm the one who is deluded, how come I'm the only one of us actually presenting a rational argument using sound logical practice based on evidence and the application of the principle of parsimony, while the people that call me deluded resort to the use of logical fallacies like appeals to authority and tradition?" Maybe I really am deluded, but bald faced assertions with no argument supporting them certainly is not the way to establish that.

Asking whether the growth rate causes autism or autism causes the growth rate is circular nonsense. The atypical aspects ARE AUTISM. Or some other word we later decide to use to represent it. We are talking about the broad strokes "Pervasive Developmental Disorder" AKA the Autistic Spectrum. Autism is the name given by science to the collection of noticed differences. The name given for Atypical Developmental Functions, not the atypical presentations, the qualities that caused an atypical presentation. Stop staring at fingers and look at the moon the fingers are pointing at.



AuntyCC
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15 Jul 2009, 3:13 pm

fiddlerpianist wrote:
I'm highly skeptical that this would work. Maybe in the absolute mildest of cases, but even then I doubt it. How many anecdotes have we heard here on WP where parents have more-or-less tried to make their child "normal," only to fail miserably?

The idea that parents can be "brain architects" of their children has never been proven to be effective. It only servers as fuel for companies to sell parents junk like Baby Einstein CDs, flash cards, and other forms of static learning.


The thing about anecdotes is my point exactly - it's anecdotal, not scientific evidence. It's very difficult to carry out robust case-control trials of early intervention methods. So a parent might do everything they can think of including taking advice from speech therapists and other professionals and after years of effort their child may still not speak, or may speak but not interact, or may interact but oddly. What no-one can ever say is how that child would have fared without their parents' efforts.



bhetti
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15 Jul 2009, 3:20 pm

thank you, crassus.

you said "autistic neuroplasticity has been demonstrated to be different from NT neuroplasticity via brain scans." which I think is the core issue.

I think people mistake "brain plasticity" for "I can change myself into whatever I want", which is not true.



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15 Jul 2009, 3:43 pm

Janissy wrote:
I tend to think not. Why? Because of the many parents who have kids who are both AS and NT. On WP alone there are NT parents who have both AS and NT kids and AS parents who have AS and NT kids. If the parents were able to influence the architecture that much, one way or the other, it stands to reason that families with multiple kids wouldn't have a mix of AS and NT because even though parents adapt their style to suit the kid (or ought to), no parent changes their style so much from one kid to the next in a way that could explain having kids who are both AS and NT. There is one parent I read on the parenting forum who has a kid who is pretty low functioning and one who is Aspergers. I can't imagine any parenting style that would change so drastically between kids.

Speech therapists can't catch a speech delay until a kid is past the age when most kids talk (2). This happened with my daughter and it's when her interventions started (only speech, at that young age- since her diagnosis was "speech delay"). There are attempts to find diagnostic criteria for babies but it's so iffy at that young age. I have 20/20 hindsight now but what set my daughter apart from other kids is that she screamed constantly. In retrospect she was overstimulated by things that don't overstimulate other babies- too much sensory input to process. That would be the big clue if...if...if constant crying was unique to autistic babies. But it isn't. The thing about babies is they have so few behaviours that behaviours can't be diagnostic. My daughter cried constanly. But so do babies with acid reflux disease, with any number of diseases, really. There are myriad reasons for babies to cry constantly. And some babies are utterly NT and have no health problems like acid reflux yet scream inconsolably until suddenly they don't. (me, I'm told.) And even then, many babies who will be diagnosed somewhere on the spectrum don't cry much at all.

Then there's the other conundrum. What intervention do you give a baby to grow NT brain architecture. You can give toddlers speech therapy (my daughter had her share). I've heard you can start ABA therapy for some things in toddlerhood. But nobody really understands the architecture of the brain well enough to even have a clue what the intervention would be. When I was pregnant my Mom gave me a book about helping babies brains develop which gave some reasonable advice- talk to the baby, play with the baby, take the baby places, plunk the baby down amongst other people and let them talk to and play with the baby. That does sound like a recipe for raising a very typical, mentally healthy baby. I did all that (it actually does come pretty intuitively) but it didn't seem to work out as well in practice as it looked on paper. (I hadn't heard of autism at that point, nor did any doctor say anything other than "colic".) In retrospect, that would be because of sensory issues.

Bruno Bettleheim (may he burn in Hell) certainly did believe that NT mothers could convert NT children into AS children by not loving them. In fact, he was of the opinion that it ALWAYS happened that way. So naturally I'm pretty leary of the whole "it's how you raise them" idea in general.


Janissy, thanks for the reply. Let me be clear when I say I think it might be possible to change the architecture I don't mean totally, or in all cases. I just think that change is possible. I don't believe for a second in Bettleheim's theory.

What I do mean is that it seems plausible that some, maybe many people with the autistic type brain at birth might be able to alter some parts of their brains to some extent. Conversely, people with the neurotypical brain at birth might alter some parts of their brains to manifest autistic behaviours in some areas of their lives.

The sort of thing I have in mind is exactly what you've done with speech therapy and socialising - as I say maybe it does work to some extent for some children. The opposite of that is for a child born to an AS mother who simply does not have many friends, who finds socialising difficult, and who interacts with people oddly, struggles with child's friends, gives child counterproductive advice for dealing with friendship difficulties. It seems to me that any child has a better chance if they have a strong role model for social behaviours. Some children seem to be socially gifted and immune to any influence from more awkward parents.

However I was not only thinking of social behaviours, I was thinking about the cognitive aspects like finding it hard to hear a voice through background noise. An AS baby whose parents prefer quiet might do better at learning to listen than one whose parents (like most normal people) have a radio, TV or music on most of the time.

And, in case anyone thinks I've run off topic, I'm convinced that any demonstrated behavioural change has to reflect an architectural change, even if it is some kind of bypass or extension or bridge or other workaround.



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15 Jul 2009, 4:51 pm

Fascinating topic! If one were to attain Aspergian traits through experiences while growing up, I wonder what that would be called. If one were to attain enough to meet the DSM criteria for example, would that person be diagnosed AS or something else?


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Callista
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15 Jul 2009, 5:34 pm

Probably AS. It's just that the odds of getting all those traits together for some other reason than being genetically destined to get them is really quite unlikely.


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15 Jul 2009, 5:59 pm

Crassus, to whom was your post directed? The second person seems to have shifted mid-post.

In your response to the circular reasoning regarding autism and brain growth, I suppose it depends on your definition of autism. If by autism you mean fundamental neurological difference, then you are correct. If by autism you mean the traits which are indicative of the position (probably the more commonly accepted definition), then it's a different story.

If you really are talking about a fundamental difference in brain structure, then those differences should manifest in every autistic person, right? Is it a stretch, then, to assume that there should be some sort of physical test which can be performed which yields definitive results? As someone else said, these studies only show differences between groups of autistics and non-autistics. Why would some autistics show no detectable sign of this "hard wiring" (for lack of a better term)?

By the way, you bring up excellent and fascinating points. I am thoroughly enjoying this discussion.


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15 Jul 2009, 7:10 pm

fiddlerpianist wrote:
Why would some autistics show no detectable sign of this "hard wiring" (for lack of a better term)?

Because there is no one universal cause for having a different neurology, unless you know what you are looking for you are not going to find it. Also, for some differences, they are not going to show up unless invasive procedures are used (at our current knowledge).



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15 Jul 2009, 7:19 pm

Callista wrote:
Probably AS. It's just that the odds of getting all those traits together for some other reason than being genetically destined to get them is really quite unlikely.


See if this scenario sounds plausible. A kid who is gifted, parents who are intellectual (engineer and teacher) who moves every couple of years, raised in a cult religion, and child of an alcoholic. That kid is likely to be shy. The shyness feeds on itself. Little reality checking from having many friends leads to eccentric traits. Seeing people react to these eccentricities leads to not wanting to meet their gaze. Special interest research is likely from being gifted. Lack of practice leads to not having social skills. Skipping a grade at a young age led to some anxiety, which exacerbated the effect. This scenario is not hypothetical, but personal experience.



Last edited by Rocky on 16 Jul 2009, 1:52 am, edited 1 time in total.

bhetti
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15 Jul 2009, 7:44 pm

Rocky wrote:
See if this scenario sounds plausible. A kid who is gifted, parents who are intellectual (engineer and teacher) who moves every couple of years, raised in a cult religion, and child of an alcoholic. That kid is likely to be shy. The shyness feeds on itself. Little reality checking from having many friends leads to eccentric traits. Seeing people react to these eccentricities leads to not wanting to meet their gaze. Special interest research is likely from being gifted. Lack of practice leads to not having social skills. This scenario is not hypothetical, but personal experience.
your personal experience does not preclude the child being on the spectrum (as well as its parents) and the closed-system upbringing does nothing to teach the child how to cope (in fact it just reinforces the social issues and tendency to isolate - this one I know well from experience). your example does not support an environmental cause for autism, it only illustrates what happens when people on the spectrum breed and raise their kid(s) without noticing they have special needs.



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15 Jul 2009, 11:03 pm

AuntyCC wrote:
fiddlerpianist wrote:
I'm highly skeptical that this would work. Maybe in the absolute mildest of cases, but even then I doubt it. How many anecdotes have we heard here on WP where parents have more-or-less tried to make their child "normal," only to fail miserably?

The idea that parents can be "brain architects" of their children has never been proven to be effective. It only servers as fuel for companies to sell parents junk like Baby Einstein CDs, flash cards, and other forms of static learning.


The thing about anecdotes is my point exactly - it's anecdotal, not scientific evidence. It's very difficult to carry out robust case-control trials of early intervention methods. So a parent might do everything they can think of including taking advice from speech therapists and other professionals and after years of effort their child may still not speak, or may speak but not interact, or may interact but oddly. What no-one can ever say is how that child would have fared without their parents' efforts.

While there may not be scientific evidence to suggest that parental intervention doesn't make a difference to brain architecture, there isn't scientific evidence to suggest that parental intervention can make a difference to brain architecture, either. I guess my intuition says that the former is more plausible, given that children are individuals and not simply products of their parents' plans. This has been demonstrated time and time again, both inside and outside of autistic families.


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15 Jul 2009, 11:33 pm

Rocky wrote:
Callista wrote:
Probably AS. It's just that the odds of getting all those traits together for some other reason than being genetically destined to get them is really quite unlikely.


See if this scenario sounds plausible. A kid who is gifted, parents who are intellectual (engineer and teacher) who moves every couple of years, raised in a cult religion, and child of an alcoholic. That kid is likely to be shy.
The shyness feeds on itself. Little reality checking from having many friends leads to eccentric traits. Seeing people react to these eccentricities leads to not wanting to meet their gaze. Special interest research is likely from being gifted. Lack of practice leads to not having social skills. This scenario is not hypothetical, but personal experience.

I’m not saying such a situation is not plausible but I fail to see what it has to do with AS. Being shy and not practising social skills cannot produce the social deficits in AS. Being too shy to look someone in the eye is not the same as an inability to use eye contact to regulate expression.

What you describe is not cause to rule out AS, but it’s not cause to suspect it either.



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15 Jul 2009, 11:35 pm

We are not badly wired robots domed to spend our lives as broken machines ! !! !

Is there anyone here who can honestly say that nothing has helped them, that they are still incapable of change ???


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