On the relationship between autism and evolution

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andrew_w
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01 Apr 2011, 2:15 am

Kon wrote:
Isn't one of the core elements of ASD an abnormal absorption with the self? Are there any people with ASD for whom this doesn't apply?


It seems that the majority of autistics have a rather different experience of self, and many superficially appear to be self-absorbed, but I suspect that the primary difference in experience of self in autistics is significantly reduced capacity for processing self and other simultaneously, rather than simple "self-absorption". "No self/all other" and "no self/no other" modes of thinking are probably just as common in autistics as (if not more common than) "all self/no other".



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01 Apr 2011, 9:35 am

wavefreak58 wrote:
If the line were autism/not autism, maybe. But the lines are blurred not only along the autism spectrum, but across multiple psychiatric disorders as well. Hard science requires crisp definitions, objective measures, and reproducible results. None of these exist in the current diagnostic process.


Because none of them exist in reality. There are no hard and fast boundaries between neuropsychological diagnoses, because those diagnoses are merely trends. They are heterogeneous and overlapping.

Take intellectual disability. There are many, many brain abnormalities that can result in ID. So why bother diagnosing people with ID? Simple--because the diagnosis has utility. It says something important about the people in question. The point of diagnosing something with ID is not to pinpoint exactly where and how their brain is abnormal--it's to, for example, give parents an idea of what they can expect for their child's future.

Same thing for autism. There are many, many brain abnormalities that can result in autism. So why bother diagnosing people with autism? Again, because the diagnosis has utility. It says something important about the people in question. The point of diagnosing something with autism is not to pinpoint exactly where and how their brain is abnormal--it's to, for example, give parents an idea of what they can expect for their child's future.

Quote:
The hard science happening in brain and cognition research is much more compelling to me than the fuzzy boundaries between DSM-IV diagnoses. I suspect that has the hard science progresses, it will force restructuring of more diagnostic categories than just autism.


The "hard science" and "fuzzy diagnostic categories" will never be reconciled--they're not supposed to. Autism is supposed to describe a variety of brain abnormality.

You are missing the "point" of autism completely. Trust me.



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01 Apr 2011, 9:48 am

Poke wrote:
wavefreak58 wrote:
If the line were autism/not autism, maybe. But the lines are blurred not only along the autism spectrum, but across multiple psychiatric disorders as well. Hard science requires crisp definitions, objective measures, and reproducible results. None of these exist in the current diagnostic process.


Because none of them exist in reality. There are no hard and fast boundaries between neuropsychological diagnoses, because those diagnoses are merely trends. They are heterogeneous and overlapping.

Take intellectual disability. There are many, many brain abnormalities that can result in ID. So why bother diagnosing people with ID? Simple--because the diagnosis has utility. It says something important about the people in question. The point of diagnosing something with ID is not to pinpoint exactly where and how their brain is abnormal--it's to, for example, give parents an idea of what they can expect for their child's future.

Same thing for autism. There are many, many brain abnormalities that can result in autism. So why bother diagnosing people with autism? Again, because the diagnosis has utility. It says something important about the people in question. The point of diagnosing something with autism is not to pinpoint exactly where and how their brain is abnormal--it's to, for example, give parents an idea of what they can expect for their child's future.

Quote:
The hard science happening in brain and cognition research is much more compelling to me than the fuzzy boundaries between DSM-IV diagnoses. I suspect that has the hard science progresses, it will force restructuring of more diagnostic categories than just autism.


The "hard science" and "fuzzy diagnostic categories" will never be reconciled--they're not supposed to. Autism is supposed to describe a variety of brain abnormality.

You are missing the "point" of autism completely. Trust me.



We disagree on a fundamental level. Trust me.

The lack of quantifiable criteria for psychiatric diagnoses is not by design. It is by default. If the psychiatric community declines to implement quantitative measures and processes, then it will eventually be supplanted by a system that does.


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02 Apr 2011, 6:23 pm

wavefreak58 wrote:
We disagree on a fundamental level. Trust me.


What, exactly, is our disagreement? I don't see a disagreement--I see misunderstanding.

Please note that my description of autism as a heterogeneous "label" that can be the result of a variety of brain abnormality is, for all intents and purposes, universally supported by the communities of science and medicine. The only people who are out trying to "pin down" a homogeneous basis for autism are people who either don't understand what autism is, or people who are simply trying to identify one "brain state" or neurological "trend" among the many that can result in autistic behavior.

If I may, two more pertinent google searches:

"autism is a heterogeneous"
http://www.google.com/search?hl=en&safe ... =&aql=&oq=

"autism is a homogeneous"
http://www.google.com/search?q=%22autis ... b&filter=0

Please note that there are 42,000 results for the former search, and fewer than ten for the latter. Please note that the few results that the latter search did produce are almost all instances of people denying the erroneous assumption that autism is a homogeneous condition.

Now, just to cover my own ass here--my point is not anything so puerile as "more results = truth". My point is, read the writing on the freakin wall. Read some of the 42,000 results returned by the first search. Educate yourself. Because, as of now, right now, in regard to the issue at hand, you are stuck in the dark ages.

Quote:
The lack of quantifiable criteria for psychiatric diagnoses is not by design. It is by default. If the psychiatric community declines to implement quantitative measures and processes, then it will eventually be supplanted by a system that does.


You really don't get it. Not trying to be a jerk here, just being honest. The value of any diagnosis relates to its utility. Until you can understand how "general", heterogeneous diagnoses can have utility, you will not understand autism.



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02 Apr 2011, 6:50 pm

Poke wrote:
wavefreak58 wrote:
We disagree on a fundamental level. Trust me.


What, exactly, is our disagreement? I don't see a disagreement--I see misunderstanding.

/quote]

I see the fuzziness of current diagnosis as a problem. You don't. I understand perfectly what you are saying. I just think it's wrong. A great deal of suffering happens because the fuzziness of psychiatric diagnoses leads to poor choices for treatment. The way behavioral traits are defined allow for so much subjectivity it's no wonder so many are misdiagnosed. I don't understand how you can't see the problem with this.

A list of behavioral traits that defines a disorder is subject to change and the interpretation bias of the practitioner. A specific brain anomaly can't be second guessed. It exists or it does not. These brain lesions will become the foundation for diagnosis, not behavioral categorizations based on the whims of of the current psychiatric status quo.

Case in point. How long has it been since homosexuality was removed from the DSM? (1973 in case you're interested) What changed? Certainly not science. Do you really trust the definition of autism to the same process that not so long ago considered homosexuality as a disorder needing treatment?


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02 Apr 2011, 7:32 pm

Again, you just don't seem to get it. You don't get the "point" of autism as a diagnosis.

Go back to my example of intellectual disability. I quote:

Quote:
Take intellectual disability. There are many, many brain abnormalities that can result in ID. So why bother diagnosing people with ID? Simple--because the diagnosis has utility. It says something important about the people in question. The point of diagnosing something with ID is not to pinpoint exactly where and how their brain is abnormal--it's to, for example, give parents an idea of what they can expect for their child's future.

Same thing for autism. There are many, many brain abnormalities that can result in autism. So why bother diagnosing people with autism? Again, because the diagnosis has utility. It says something important about the people in question. The point of diagnosing something with autism is not to pinpoint exactly where and how their brain is abnormal--it's to, for example, give parents an idea of what they can expect for their child's future.


Do you honestly not understand what I'm saying?



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02 Apr 2011, 9:03 pm

Poke wrote:
Again, you just don't seem to get it. You don't get the "point" of autism as a diagnosis.

Go back to my example of intellectual disability. I quote:

Quote:
Take intellectual disability. There are many, many brain abnormalities that can result in ID. So why bother diagnosing people with ID? Simple--because the diagnosis has utility. It says something important about the people in question. The point of diagnosing something with ID is not to pinpoint exactly where and how their brain is abnormal--it's to, for example, give parents an idea of what they can expect for their child's future.

Same thing for autism. There are many, many brain abnormalities that can result in autism. So why bother diagnosing people with autism? Again, because the diagnosis has utility. It says something important about the people in question. The point of diagnosing something with autism is not to pinpoint exactly where and how their brain is abnormal--it's to, for example, give parents an idea of what they can expect for their child's future.


Do you honestly not understand what I'm saying?


If you are talking to me then it is you that doesn't get it. You are fixated on a particular concept of autism, as if that is the penultimate definition. I am saying that the very definition of autism that you adhere to is flawed. You can argue all you want from a flawed position, and your result will be equally flawed.


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27 May 2011, 10:15 pm

The story linked in this thread is interesting:

http://www.wrongplanet.net/postt162982.html

From the story:

http://www.webmd.com/brain/autism/news/ ... mal-brains

Quote:
Normal brains, they found, are alike in that for about 500 genes, gene expression in the temporal lobes -- which regulate hearing, language, and the processing and interpreting of sounds -- is very different from gene expression in the frontal lobe, which plays a role in judgment, creativity, emotions, and speech.

But in as many as 75% of the autistic brains there was very little difference in gene expression between the temporal and frontal lobes.

In the autistic brains, genes related to synaptic function -- information sharing between neuronal brain cells -- were turned down to low levels of expression.

"This points to a developmental patterning defect," Geschwind says. "That means the usual patterning of the brain -- the way different parts of the brain hook up -- might be altered in autism."

"This supports a longstanding view that the development of normal brain physiology is disturbed in autism," Ring says. "Up to this point, we have been limited to trying to deduce from the genetic findings. Here we have specific evidence that something has gone wrong during development."


The study is here:

http://www.nature.com/nature/journal/va ... E-20110526



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01 Jun 2011, 6:00 am

I read something yesterday that made me think of this thread. I'll share it after I respond to a post from several pages back.

Bluefins wrote:
Poke wrote:
wavefreak58 wrote:
Deviance becomes bad at what point? Without deviance there is no genetic 'experimentation' with potentially beneficial change.


It might be helpful to remember that the point of my original post was not that "deviance = bad" in any intrinsic sense, but that natural selection rewards (and predisposes us toward) normality.

Thanks, and that's false. Natural selection rewards fitting your environment, which doesn't care at all about normality.

Image


Note that natural selection only describes the change--from large to small, in the case of the giraffes. You will note that, despite the change in each type, there is a great deal of stasis from example to example. The clams look almost identical. Same goes for the lizards and giraffes. In each case, there is a general uniformity of form (I know, that sounds awful) across the changes depicted. The dynamic I'm describing relates to that stasis, and, while it isn't the same as natural selection, it's something of a logical extension of it. Natural selection does reward a predilection toward normality--in a roundabout way by means of the dynamic I've described.

Anyway, I was reading Stephen Jay Gould's essay, Betting On Chance--And No Fair Peeking and was struck by this passage:

Quote:
If selection controls evolutionary rate, one might think that the fastest tempos of alteration would be associated with the strongest selective pressures for change. Speed of change should vary directly with intensity of selection. Neutral theory predicts precisely the opposite--for an obvious reason once you start thinking about it. The most rapid change should be associated with unconstrained randomness--following the old thermodynamic imperative that things will invariably go to hell unless you struggle to maintain them as they are. After all, stability is far more common than change at any moment in the history of life. In its ordinary everyday mode, natural selection must struggle to preserve working combinations against a constant input of deleterious mutations. In other words, natural selection, in our technical parlance, must usually be "purifying" or "stabilizing." Positive selection for change must be a much rarer event that watchdog selection for tossing out harmful variants and preserving what works.


What a brilliant way of putting it.