When I was in my 20s I had flu and had to do a music performance, so I swallowed a box of Beechams Hot Lemon Powders just to get me through it......I felt great by the time I was on stage, and performed better than usual. As those powders contain caffeine (can't see anything else in there that would do much), I figured that must be the active ingredient, so I started taking Pro-Plus. But I stopped that when I used it for a party and got palpitations. I started to feel paranoid and had to go home....luckily the guy I'd gone there with didn't think much to the party so he was happy to return home with me. Can't say I ever felt more able to empathise on caffeine.
I've been told that I perform better socially when I use cannabis - one lady said it was the only time I said what I meant. Don't know whether it was a direct psychoactive effect or if it was just the analgesic effect reducing my general bodily discomfort and calming me down. But cannabis isn't really a stimulant.
It's possible that alcohol helps slightly, though mostly it just seems to make me a bit more witty, it doesn't really make me feel that I understand people's feelings any better.
Psilocybin really did seem to enable my empathy......particularly one night when for the first time I could see my alcoholic girlfriend's plight from her own perspective, as if it were me. I suppose it could have been an illusion, I would also get feelings of oneness with nature, plants seemed sentient, and inanimate objects seemed alive....and it's not a stimulant as far as I know.
I've always felt right on the edge of a breakthrough with empathy, as if it's something I could do really well if I were to just find the right road. It's entirely possible that chemicals could make the necessary brain changes to get a person there, but I hope there's a less risky way. Drugs have a way of losing their usefulness if you make a habit out of them. I think with empathy it's probably more wholesome to just try and pay more attention to people, to unlock the secrets of what they might be feeling, and why, and how to respond. I'm often ashamed of the poor understanding I have of the emotional states of my friends. I care about them a lot, but they're like matchstick figures to me in many ways.