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It's kind of humorous you're asking a forum full of autistics on something a bit like social etiquette.
Hmm.. I'd have to agree with this a bit.
I think the proper ettiquette would be to let her bring it up.
But you could sent her a short email indicating that you are available in the event that she feels a need to talk, or a shoulder to lean on. Then wait and see. The fact that you are stating this wish to her, so soon after the 'vacation', may suggest to her that you noticed the oddities and lead to said discussion.
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By simply doing what they are designed to do something large and magnificient happens. In this sense they show us how to live; The only barometer you have is your heart. When you spot your flower, you can't let anything get in your way. - John Laroche