This is one that is difficult to determine, as to whether it's based on genetic make-up, or years of persecution from peers.
I've had people say that I get upset too easily, over certain things said - and while the consternation may be directly linked to my Aspie-ness, it's entirely possible that it's a by-product of interpreting things literally or not getting jokes, not seeing the humor or deliberate exaggeration in something. This has happened less as I've gotten older, but I definitely find myself getting upset over people criticizing me, like at work or my wife, and I think sometimes it's linked to my Aspie traits, but then again sometimes it's not. That's where it's hard to tell the two apart sometimes. I think this is where Aspies might be "thin-skinned" because certain things said will "get to them" which wouldn't get to NT's, and unfortunately certain NT's like to push those buttons to spark a reaction.
When people yell at me, I do definitely cringe, and get upset - and I do tend to ruminate it on it much longer than the typical person; I know this is due to the "feedback loop" that is characteristic of AS and OCD, where they dwell on something negative for an inordinate period of time and can't "let it go".
At work this is where having a thick skin can be challenging, some roles more than others. Sometimes we feel targeted b/c of our difference; sometimes, it's ostensibly not personal. Giving an example: my first job out of university was a technical support rep b/c I was a (stereotype)
computer wiz, and the somewhat routine nature of problems suited me. However, I tended to have a shutdown mechanism when customers would get angry with me, and had to forcibly think myself it wasn't personal so I could concentrate on calming them down and diffusing the situation. Most of the time it worked
however, there was one time that had me on the brink of tears, one nasty lady who sounded in her 60s was giving me hell about how I'm proof that you can't speak to a human being "these days" at call centres, you can only speak to a robot and I sound like a robot, she accused me of only hearing what she was saying and not really listening, and she wanted to know if I'm really a robot underneath. (this was a couple of years before my diagnosis, so it sounded all the more unjustified). I assured her I was not, but she replied "I don't think so!! ! Go F*** yourself, you heartless machine!!" and slammed the phone down.
She could have easily said that to one of my NT colleagues, but I concluded that she picked up on my AS.
Call me thin-skinned for my upset over that episode, but it definitely stayed with me for a while.