I keep two stuffed animals at my desk at the lab, one of them being a polar bear.
One of my coworkers (NT) remarked, "how weird, why do you have a stuffed polar bear here? Aren't you kinda old for that?"
I replied, "oh, I just like it, and I'm trying to personalize my desk space and make it more comfortable for me." I then proceeded to act as though the bear was going to eat her ear, making growling noises in the process.
Then she saw the other stuffed animal. "What's this?" she asked.
"Oh, that's a poison dart frog. I got it from the Aquarium of the Americas in New Orleans before Hurricane Katrina hit."
Then she shut up and just walked away.
Good reply! I probably would have responded to her the same way.
I also have stuffed animals (though not at work. I have no place to put them.) I'm 25 Iand I see no problem with it.