Stanford U & brain plasticity pill to reverse autism

Page 1 of 3 [ 33 posts ]  Go to page 1, 2, 3  Next

StillSwimming
Tufted Titmouse
Tufted Titmouse

User avatar

Joined: 9 Apr 2012
Gender: Female
Posts: 43
Location: Peru

21 Oct 2013, 4:55 pm

This Stanford scientist studied under Nobel Laureates and has made breakthrough findings about immune proteins in the brain that may hold the key to a cure for autism:

http://discovermagazine.com/2013/oct/12 ... mWTxZDn-aw



cathylynn
Veteran
Veteran

User avatar

Joined: 24 Aug 2011
Gender: Female
Posts: 13,045
Location: northeast US

21 Oct 2013, 6:05 pm

fascinating article.



AardvarkGoodSwimmer
Veteran
Veteran

User avatar

Joined: 26 Apr 2009
Age: 62
Gender: Male
Posts: 7,665
Location: Houston, Texas

21 Oct 2013, 6:28 pm

I believe in the rights of adults to terraform their own bodies.

And I think in the coming decades, for better, for worse, or probably for both, people will start to go cyborg.

Now, parents making choices for their children, that becomes a much trickier enterprise.



GregCav
Veteran
Veteran

User avatar

Joined: 16 Apr 2013
Age: 59
Gender: Male
Posts: 679
Location: Australia

21 Oct 2013, 6:30 pm

Quote:
Hubel and Wiesel had uncovered the principles of how neuroplasticity works in the brain: Basic neural architecture is hardwired. For instance, the eye is genetically programmed to connect with the visual, not the auditory, part of the brain. Fine-tuning that circuitry — connecting the eye to a specific part of the visual cortex — is shaped by experience.


To understand how this works, it helps to remember a bit more basic biology. When neurons are stimulated, they spike with enough electric current to send neurotransmitters across a tiny gap called a synapse, where other neurons, in turn, are similarly stimulated and provoked. As the signal passes down the line, entire circuits are put in play.

Neurons that handle lots of robust, well-synchronized signals sprout more neurotransmitter-generated terminals, and their connections with other neurons along the signaling pathway grow stronger. (Neuroscientists have a slogan for this: “Cells that fire together wire together.”) Synapses that transmit few, weak or out-of-sync signals are pruned away. In this way, brain circuits are remodeled with use.


This explains our sensory issues perfectly. I'm a long way from understanding how brain wiring affects emotional issues, TOM and such.

If they manage to make this placticity pill at all, what they've described in the articles is for the sensory wiring only. Perhaps they are related, one can only hope.



serenaserenaserena
Veteran
Veteran

User avatar

Joined: 19 Jul 2013
Gender: Female
Posts: 573
Location: Sinnoh Region, Pokémon World

21 Oct 2013, 8:01 pm

Why is it called a cure...? Autism isn't a sickness, and even if there are people who want to prevent it for some reason, why should it be called a cure? Why can't it be called an autism block or something like hormone blockers? The person took hormone blockers to prevent puberty. The person took autism blockers to prevent autism. Hmmmmm, that sounds about right actually.


_________________
~~~
aspie score: 166 out of 200
officially diagnosed in 2013
~~~
Pain is inevitable; suffering is optional.
~~~


StillSwimming
Tufted Titmouse
Tufted Titmouse

User avatar

Joined: 9 Apr 2012
Gender: Female
Posts: 43
Location: Peru

21 Oct 2013, 8:08 pm

Thank you Stanford! I took some online classes there and OMG, the stuff they are working on is truly mindboggling.

I cringed when she spoke about suturing the kitten's eye shut.

It seems that with autism, these immune proteins in the brain ( never thought to exist within the brain before due to blood-brain barrier) may underprune the synapses, so there are too many neural connections, more so than optimal in normal brain development. In the case of Alzheimer's, the opposite is happening: the proteins are overpruning and resulting in too few neural connections.

She said that a pharma drug could be developed to moderate the immune proteins and thereby increase or decrease brain plasticity by regulating the immune protein receptors.

What is especially great for autistics is that this should also work for other comorbid conditions like schizophrenia. Plus this would not be treating symptoms or masking them, but act as a cure by rewiring the brain.



StillSwimming
Tufted Titmouse
Tufted Titmouse

User avatar

Joined: 9 Apr 2012
Gender: Female
Posts: 43
Location: Peru

21 Oct 2013, 8:14 pm

Serena, I just saw your comment. I meant "cure" in the sense of addressing the cause of autism, rather than its manifested symptoms.

Certainly, people who like their autism don't have to take the pill.

Did not mean to offend anyone by my choice of the word "cure" - I am on your side here as fellow Aspie. :wink:



Callista
Veteran
Veteran

User avatar

Joined: 3 Feb 2006
Age: 42
Gender: Female
Posts: 10,775
Location: Ohio, USA

21 Oct 2013, 8:39 pm

I'd be cautious about making any "cure" statements, either. It sounds like you could prevent autism this way--if you weren't worried about leaving the fetus without a working immune system--but to change the brain at a fundamental level in adulthood would essentially mean erasing the connections already there. You would lose memories, learned skills, pretty much everything.

I don't think that "restoring plasticity" would break those connections--it could make it easier to learn and to repair brain injuries, maybe. But let's say that this actually works in an extreme way, allows you to remodel the basic differences that make you autistic--well, you'll be throwing your personality out the window along with your autism. It would be a second infancy, a blank slate. However much of yourself you wanted to keep, you'd have to keep that much autism, too. Become NT, and it would be someone else wearing your brain.

It might be used to prevent autism in the developing fetus, but that's pretty much it. I'm much more optimistic about its potential for helping people recover from strokes and head injuries.


_________________
Reports from a Resident Alien:
http://chaoticidealism.livejournal.com

Autism Memorial:
http://autism-memorial.livejournal.com


serenaserenaserena
Veteran
Veteran

User avatar

Joined: 19 Jul 2013
Gender: Female
Posts: 573
Location: Sinnoh Region, Pokémon World

21 Oct 2013, 8:47 pm

Callista wrote:
I'd be cautious about making any "cure" statements, either. It sounds like you could prevent autism this way--if you weren't worried about leaving the fetus without a working immune system--but to change the brain at a fundamental level in adulthood would essentially mean erasing the connections already there. You would lose memories, learned skills, pretty much everything.

I don't think that "restoring plasticity" would break those connections--it could make it easier to learn and to repair brain injuries, maybe. But let's say that this actually works in an extreme way, allows you to remodel the basic differences that make you autistic--well, you'll be throwing your personality out the window along with your autism. It would be a second infancy, a blank slate. However much of yourself you wanted to keep, you'd have to keep that much autism, too. Become NT, and it would be someone else wearing your brain.

It might be used to prevent autism in the developing fetus, but that's pretty much it. I'm much more optimistic about its potential for helping people recover from strokes and head injuries.


I agree. If people really want autism stopped, it should probably be done before birth. By all means, I really do think that it would be bad to change a person with autism after they've already developed into it and all.
If I was the leader of everything, I wouldn't want it at all, but yes, the first one is probably better.


_________________
~~~
aspie score: 166 out of 200
officially diagnosed in 2013
~~~
Pain is inevitable; suffering is optional.
~~~


AardvarkGoodSwimmer
Veteran
Veteran

User avatar

Joined: 26 Apr 2009
Age: 62
Gender: Male
Posts: 7,665
Location: Houston, Texas

21 Oct 2013, 8:48 pm

Okay, on the general question of quote cure,

I want to be appreciated for the unique, creative person I am. Not held against some overly narrow definition of normal. (and no such thing as 'normal' anyway and how boring a place the world if there were! :jester:)

And one thing which potentially can help our entire society is just broadening the definition of normal.

=========

Yes, things are big issues, difficult issues. All the same, I think they're worth discussing from time to time.



Adamantium
Veteran
Veteran

User avatar

Joined: 6 Feb 2013
Age: 1025
Gender: Female
Posts: 5,863
Location: Erehwon

21 Oct 2013, 9:15 pm

I'll be staying me, thanks all the same!

Maybe I can pop a little oxytocin before I have to go to another team building exercise at work, but that's as far as I will go. A teardown/rebuild of me? Thank you, but no.

My kids need their dad, not a reprogrammed meat puppet.



Ganondox
Veteran
Veteran

User avatar

Joined: 7 Oct 2011
Age: 29
Gender: Male
Posts: 5,778
Location: USA

21 Oct 2013, 10:16 pm

I'd rather not destroy the connections in my brain, thank you very much.


_________________
Cinnamon and sugary
Softly Spoken lies
You never know just how you look
Through other people's eyes

Autism FAQs http://www.wrongplanet.net/postt186115.html


CockneyRebel
Veteran
Veteran

User avatar

Joined: 17 Jul 2004
Age: 50
Gender: Male
Posts: 118,420
Location: In my little Olympic World of peace and love

21 Oct 2013, 11:10 pm

I'll be staying far away from those pills.


_________________
The Family Enigma


starkid
Veteran
Veteran

User avatar

Joined: 9 Feb 2012
Gender: Female
Posts: 5,812
Location: California Bay Area

21 Oct 2013, 11:32 pm

Oh great. Another sick f**k torturing one animal species to "help" another.



Marybird
Veteran
Veteran

Joined: 26 Apr 2012
Gender: Female
Posts: 1,818

22 Oct 2013, 12:01 am

Quote:
Somewhere on the campus of Stanford University, among the stately oaks and tile-roofed temples of scientific inquiry, live Carla Shatz’s super-mice. They learn complex physical tasks more quickly than their ordinary cousins. If one eye is deprived of sight, they rapidly rewire their brains to compensate, then beat normal one-eyed mice on tests of visual acuity. They recover more readily from some brain injuries, too. What sets these rodents apart is their superior ability to form new neural connections, or strengthen existing ones, in response to experience.


This sounds like something that could be applied to all humans, neurotypical and autistic, if it weren't for the incomplete immune system that goes along with it.

Imagine a race of super humans able to rapidly rewire their brains to compensate for injuries, learn complex tasks more quickly than ordinary humans, recover rapidly from brain injuries, easily form new neural connections in response to experience, develop superhuman visual acuity, leap tall buildings in a single bound. Their only weakness, (no not kryptonite), no immune system!

The thought of a treatment that would alter the way my brain worked is frightening to me.



Joe90
Veteran
Veteran

User avatar

Joined: 23 Feb 2010
Gender: Female
Posts: 26,492
Location: UK

22 Oct 2013, 12:02 pm

I don't understand the science part of it, but I WANT TO TAKE THE PILL!! !! Even if it makes me more intellectually stupid or something, I don't give a f**k about that. I just want to be able to be more social without having something offish about me. Please make into that, please????! !! !! !! !! !! !! !! !! !! !! !! !


_________________
Female