Paradox reaction to Antipsychotics? (read More Paranoia!)

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omid
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05 May 2014, 8:03 am

Hello,

I've read somewhere (again, not sure) that people with ADHD and (maybe?) Aspergers have often paradoxical reaction to tranquilizers and sleep meds and such which makes them rather hyper. I defenitely have had a horrible reaction to ambien. I stayed very much awake and talked crap and couldn't remember anything the next day. and my kind family had filmed the whole thing. watching that 1.5 hours footage was aaawkkkward!! !! !! !! !

so back to my actual question. I was very restless recently and my doc prescribe me Perazine ( very similar to thorazine ) in addition to my 30mg of zyprexa. and now I get quite paranoid when I go out. Ok maybe not paranoid but anxious. like i always like to wear a cap even when it's warm out there and yesterday I went out WITH companion (alone is impossible) I had the feeeling that someone would ridicule me or start a conversation with me about why I'm wearing a hat in hot weather. So i took of my cap and then I even felt worse because I NEEDED MY CAP!

I'm taking 200 mg of Perazine which is an Antipsychotic dosis on its own + 30mg olanzapine (Zyprexa). and before the Perazine I was much MUCH less paranoid. Oh sorry anxious. who cares. I'm also on topamax and opipramol if that matters. Can I be having an anticholinergic toxicity? 3 meds with antichlinergic activity. makes sense.
does paradoxical reaction only apply to restlessness and hyperness or does it also apply to other symptoms? like psychosis and hallucinations? I had 2 visual hallucinations yesterday but I get them every once i a while so I dont know whether these are Perazine related. (but probably yes. to be honest they were more than 2)

cheerz
omid


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GlennBecksTears
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05 May 2014, 8:13 am

for me personally Topamax always made me paranoid. I'm paranoid iin general but a dose of Zyprexa takes care of that. When I take it, that is.



zer0netgain
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05 May 2014, 8:41 am

Any of the brain chem drugs are more voodoo than science.

Even for NTs, the warnings are clear that an anti-psychotic or anti-depressant can actually make the patient MUCH WORSE than they were without the drug.



neobluex
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05 May 2014, 9:01 am

Is perazine approved in the US?



LabPet
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05 May 2014, 9:47 am

Neuroleptics (aka anti-psychotics) are not indicated for any autistic spectrum condition, including AS. I am dismayed and perplexed when any Aspie is prescribed neuroleptics; AS is not a psychotic disorder and these drugs are contraindicated because of their potentially harmful long-term effects.

Look, I understand that AS can be anxiety provoking, but neuroleptics are the wrong tact. Certainly they are not appropriate as a sleep-aid! Please be really careful, and do get a new physician who is more knowledgeable and competent.


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neobluex
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05 May 2014, 6:09 pm

LabPet wrote:
Neuroleptics (aka anti-psychotics) are not indicated for any autistic spectrum condition, including AS.


Risperidone and aripiprazole heve been approved for irritability associated with autism. Ziprasidone and paliperidone are used off-label to treat serious behavior disorders.



LabPet
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05 May 2014, 7:18 pm

neobluex wrote:
LabPet wrote:
Neuroleptics (aka anti-psychotics) are not indicated for any autistic spectrum condition, including AS.


Risperidone and aripiprazole heve been approved for irritability associated with autism. Ziprasidone and paliperidone are used off-label to treat serious behavior disorders.


Anybody can be prescribed an antipsychotic. There are no restrictions as to who these drugs can be prescribed to. Rather, the point is that autism is not a psychotic disorder; quite the contrary. That fact that antipsychotics are used to 'dull down' emotions is really a misapplication......this is the fault of psychiatrists.


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Noetic
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06 May 2014, 12:11 am

I know that ADHD drugs increase the amount of Dopamine available in your brain. Therefore my guess would be if you react by calming down and so on when on ADHS meds, then antipsychotic medications, which cut the dopamine available, probably won't be such a great idea.

Reality is likely a lot more complex, though.



neobluex
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06 May 2014, 6:52 am

LabPet wrote:
Anybody can be prescribed an antipsychotic. There are no restrictions as to who these drugs can be prescribed to. Rather, the point is that autism is not a psychotic disorder; quite the contrary. That fact that antipsychotics are used to 'dull down' emotions is really a misapplication......this is the fault of psychiatrists.


It's a question of biological effects, not nomenclature. Neuroleptics are useful to control symptoms that are not manageable by other means (or are more "gentle" than those "other means").