I tried to when I was 7, but then realized I couldn't carry all my books... I told my parents I was running away and they laughed as I tried to lug all my books in a crate.
I never ran away, but I had my "hide outs" as a teen and I went on "regular" wanderings. I would take off on my bike and ride for miles. I lived in the woods and had a special rock I hung out at by myself. I always let people know that I was heading "out" as a courtesy. No one asked when I was coming back (unless to see if I'd be back by supper), so I guess they assumed I *would* be back.
In college, I occasionally skipped class to head out to walk. Mostly, I would try to fit in a long walk in-between classes. I usually tried to find somewhere remote.
When my kids were young, this was the hardest time because I was a stay at home mom and the kids were too little to leave alone. My husband was working a tremendous amount and in school for a while, so I had NO TIME TO MYSELF EVER. I was going nuts not being able to just "drop life" and leave. Out of the need to responsibly care for the children, I had no choice but to ignore the desire to ditch.
Now that they are teens, I am free again to take off, and I do sometimes. If I had the money (and a freer schedule), I would take off for a weekend by myself. But since I don't, I will take a few hours to get away. I usually hike/get out into nature. I call it "needing to clear my head." It seems the busier I get or the more stressed, the more I need these. I can feel the "four walls" of life closing in on me.
I would absolutely hate it if I had a schedule with no flexibility in it. If I had to be at a work place all day everyday and the only time I could get a break was with a scheduled day off, I'd go nuts. I need to be able to spontaneously take off if the weather is nice. I did that just last week, two days. It's part of how I regulate my mental health.
I think it is responsible and respectful to let someone know you are heading out and how long you will be. You don't want to make them wonder if something bad has happened. Also, it is nice to let them know where you are going/how to reach you, in case of an emergency.
My autistic uncle would often take off and not meet up with his ride where & when it was agreed upon. This was long before the days of cell phones. That was not cool. The police were often called to help find him. A neighbor's autistic daughter has run off before (young - under 10 at the time.) That was not cool, either. We live deep in the woods - not a great place for a kid to wander off. The parents were especially concerned because I think they were threatened with being accused of negligence if the police had to help find their daughter again. I know other parents of autistic kids who have to find ways to lock their kids inside the house so they don't escape unnoticed. It's hard!