Depending on how you mean it, I don't think so. Everyone is different, and maybe there are some manipulative aspies, but I don't think that manipulation is likely from an aspie. However, Asperger's syndrome and Borderline Personality Disorder can look very, very similar at first glance, and borderlines definitely ARE manipulative.
However, if what you mean is "Can somebody with AS learn to mimic social skills and 'manipulate' people into believing that they are an NT" or "Can somebody with AS make somebody feel manipulated," then I'd have to answer yes. Also, someone with AS is quite likely to give incorrect impressions on things (act like they're interested in something they're not, act like they're not interested in something they are, etc) but this is more likely to be something very unintentional that is simply a result of not knowing how to express themselves in a normal manner. For example, an aspie who wants to be liked and wants to have friends may give the impression of romantic interest even if they have none. It's not that they're trying to give that impression, it's that showing interest in people is difficult, particularly that correct balance. It's something that's difficult for NTs, as well, but is much more pronounced in aspies. An aspie may have been told that they seemed too aloof and uninterested in people, make an effort to seem more interested, and therefore seem to be "leading someone on" in their effort to show interest in other people.