Why apigenin works? serotonin transporter in ASD?Help me out

Page 1 of 1 [ 3 posts ] 

omid
Deinonychus
Deinonychus

User avatar

Joined: 1 Dec 2006
Age: 42
Gender: Male
Posts: 323

25 Mar 2018, 6:32 am

I'm just trying to connect the dots here, but unfortunately I'm not smart enough.
I'm kind of getting the clue from different studies, that The serotonine transporter (and maybe other monoamine transporters) might be kind of different in (some) people within the spectrum, but I totally can't figure out in what way. I mean there are two possibilities, either they don't work enough (which would mean we are on large doses of antidepressants without taking any). Or they work too good and we might have to take antidepressants to normalize that. But my intelligence fails to figure out the studies out there, particularly this one: Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior

In my case, it would make lots of sense that MY serotonine transporters (and maybe monoamine transporters) are not working well enough, as I go bats**t crazy if I take antidepressants.
This whole idea started when I started taking Chamomile extract for no good reason and started to feel really better. And guess what: There are luteolin and apigenin in that, which are according to wikipedia two of the very few know moniamine transporter ACTIVATORS (!). Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt.

I think I'm up to something. Much less breakdowns and meltdowns and shutdowns.
This is really relevant to my interests. I really need to know whether ASD people have hyperactive or hypoactive monoamine transporters, which would lead to too little / too much serotonin/Dopamine/NE in the synaptic cleft, respectively.

edit: another study I can't make sense of: Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene


_________________
Male
Aspie score: 131 of 200
NT score: 34 of 200
Possibly Aspie (diagnosed by an autism expert, doc moves abroad, forced to change docs and all say it's schizophrenia NOS or schizo-affective disorde or personality disorders. initial doc was a colleague of uncle Simon btw. you do the math.). (edit: by Uncle Simon I mean Simon Baron Cohen. Just to clear things up.)


magnum233
Sea Gull
Sea Gull

User avatar

Joined: 27 Jun 2015
Age: 45
Gender: Male
Posts: 247
Location: New Zealand

31 May 2019, 7:47 am

omid wrote:
This whole idea started when I started taking Chamomile extract for no good reason and started to feel really better. And guess what: There are luteolin and apigenin in that, which are according to wikipedia two of the very few know moniamine transporter ACTIVATORS (!). Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt.

I think I'm up to something. Much less breakdowns and meltdowns and shutdowns.


Hello, ive recently stumbled upon something that might be of interest to you.
https://greece.greekreporter.com/2014/0 ... -children/

Seems luteolin reduces brain inflammation which is why you started to feel better. Ive done some research, the highest content of luteolin in any natural substance is Mexican Oregano https://www.ars.usda.gov/ARSUserFiles/8 ... lav3.2.pdf. I propose soaking some Mexican Oregano perhaps two teaspoons in a bottle of olive oil and taking a teaspoon daily. What i shall be experimenting with in the near future. The purpose of the oil, its a carrier which enables substances to cross through the blood brain barrier thus it reaches the brain where its needed. Autism as i now understand it is a condition that inflames the brain. Find ways to reduce that inflammation you feel better.

Hope this helps. Also i know that music video in your avatar lol


_________________
Im like over there, somewhere.....


ezbzbfcg2
Veteran
Veteran

User avatar

Joined: 15 Feb 2013
Age: 42
Gender: Male
Posts: 1,977
Location: New Jersey, USA

31 May 2019, 1:06 pm

^ ^ ^What you're calling "inflammation" I think has also been called too many synapses and lack of adequate pruning. This lack of synaptic pruning leads to not only the social deficits and being "off," but all of the sensory and executive functioning problems as well. It creates too much "noise" in the brain, like overloading a computer's memory with too many programs, it slows things down and forces the computer to try and work faster, leading to burn out.

What good are all those programs if the computer can't load/run them properly? It's exhausting for the computer, and it's exhausting for the Autistic brain.

This is but one theory.