Creatine supplementation may benefit brain function, memory, intelligence, and reasoning.
Excerpt from linked article in Psychology Today:
"Creatine and the brain's energy metabolism
Our brains are incredibly energy intensive, using over 20 percent of our body's energy despite only making up around 2 percent of our weight. With this in mind, creatine's energy-supplementing effect could, in theory, present a significant benefit for the brain.
Research has revealed that supplemental oral creatine does increase the brain's creatine levels and may help counteract mental fatigue. Access to extra brain fuel may help explain the diverse brain benefits of creatine supplementation.
Creatine and memory
Creatine is somewhat unique in this regard. In a robust 2022 meta-analysis, it was concluded that creatine supplementation significantly improved memory (compared to placebo). This improvement was particularly impressive among older adults (aged 66-77).
Creatine, intelligence, and reasoning
Like memory, few supplement-based interventions are linked to improved intelligence scores. That's what makes the data on creatine all the more interesting. In a systematic review of randomized trials published in 2018, researchers concluded that oral creatine supplementation may improve healthy individuals' intelligence and reasoning abilities
Who could benefit most from creatine?
To date, the best data for the brain benefits of creatine supplementation appear to be in older adults, and potentially especially those who are vegan or vegetarian. Given what we know about its role in brain energy, it may be worth special consideration when our brains are under higher levels of metabolic stress (for example, if we're sleep-deprived or psychologically stressed)."
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