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02 Dec 2007, 8:54 am
02 Dec 2007, 4:06 pm
02 Dec 2007, 6:41 pm
Themis wrote:
Dear aspies,
My son is taking antipsychotic medication with Solyan (amisulpride) that influence glucose metabolism (I.G).This therapie is going good for 5 months.Yesterday he became agressive physically with uncotrolled and unexplained rage to his mother and he slapped her in face.What caused this brain fog?The effectiveness of Solyan (amisilpride) wore off or because of negative mechanism of action on glycose metabolism.The analyses of glucose in the next day of event (hungry) was 92 mg/dl and after 60 min 202 mg/dl.
Can you help me?
My son is taking antipsychotic medication with Solyan (amisulpride) that influence glucose metabolism (I.G).This therapie is going good for 5 months.Yesterday he became agressive physically with uncotrolled and unexplained rage to his mother and he slapped her in face.What caused this brain fog?The effectiveness of Solyan (amisilpride) wore off or because of negative mechanism of action on glycose metabolism.The analyses of glucose in the next day of event (hungry) was 92 mg/dl and after 60 min 202 mg/dl.
Can you help me?
Some antipsychotics have been linked with insulin resistance and Diabetes 2.
Even though a single glucose test is not enough for a definitive diagnosis, it's probable he's diabetic, given his glucose level of 202. A normal level lies between 70 and 110. Although beware of any glucose levels nearing either 70 or 110 because they can speak of a lesser but similar problem, like insulin resistance which can develop into diabetes.
For your son, it may be good to talk to the doctor and wean him off this medication. If they are insistent on having him on a medication of this sort, then try a different medication, perhaps risperdal, which has less of a tie to insulin problems.
If this insulin problem does not revert following med change, the boy will need to 1) go on a diabetic friendly diet consisting of high-fiber complex carbs (when any carbs are eaten), proteins, and vegetables if he'll eat them. You really need to look at what he's eating. What was this meal he had which gave him the 202. If it involved carbohydrates which are simple (sugars) or low-fiber (white breads, etc.) then these will skyrocket blood sugar and then may send the person crashing to low blood sugar awhile later. Carbs with high fiber content (wheat, brown rice, etc.) are broken down more slowly in the digestive tract, giving the body more time to produce the insulin needed. This tactic, however, doesn't work if little to no insulin is naturally being produced. But for this boy, his levels are low enough to imply he's making insulin, just not enough quickly enough.
High and low blood sugar can completely alter behavior. I unfortunately know from experience. When I get low or high blood sugar, I can become infuriated and angry at the slightest things. This is most likely what triggered his outbursts. The best medicine then is to figure out whether it's low blood sugar or high blood sugar, since cognitive symptoms can be similar. If it's low blood sugar, he needs to eat. I recommend a quarter to a half cup of juice to get the blood sugar up quickly, then followed within the next 15-20 minutes by a substantial meal consisting of high-fiber carbs and proteins (proteins also help the carbs break down more slowly in tandem with the fiber).
Given his high blood sugar, and if this is diabetes, you'll probably need to get a glucose meter to better keep an eye on his blood glucose. After awhile, if his meals and portions are consistent enough, the meter may become unnecessary if you know how a particular meal with affect his sugar levels. If his levels are high, cinnamon can help bring them down, although not quickly. Although be careful of cinnamon, it doesn't level blood sugar, it lowers it, so if used too much can lower sugar levels TOO low.
In the case of autism, this can be a tricky thing to work out a diet plan which is both diabetes friendly and sensory friendly. Find out what he likes and which also fits the diet.
No sugars except in very small quantity (the less the better because eating carbs makes one crave more, a bad cycle). I usually use simple carbs (sugar) to raise my blood sugar quickly, and then follow it with a meal. I also make sure to eat every 3-4 hours, a mix of carbs and proteins (and frequently veggies, but they are not integral to blood sugar, just general health).
As for the medical side, aside from working with his psychiatrist and the antipsychotics, I would recommend having your son's blood sugar tested again (provided it isn't putting him through too much misery) as well as having his insulin levels checked. Then, get in touch with an endocrinologist. And then a nutritionist who specializes in the variety of diabetes and insulin resistance type diets who can help you and your wife monitor your son's dietary progress.
If this problem goes away following removal of the medication, I would still recommend he be put on a diabetic friendly diet because it may show he is at a risk for developing this later on, unrelated to medications and it was the medications which simply tipped this balance. So it's best he be on a good diet starting in youth to prevent him developing this later on.
If you would like more help/info on the nutrition side from me, since I have had to treat my insulin resistance just with diet, I would be glad to help you. My email is [email protected]
