Autism Gene Research - endgame
Not sure if its been ever raised here but anyone know what the endgame of autism gene research is?
https://www.utoronto.ca/news/big-data-h ... asing-risk
The University of Toronto and it's international collaborators (including universities and hospitals here in Melbourne Australia) appear to be tracking and tracing not just the people diagnosed but they are also collecting a genetic database of all family/relatives including those antecedents and relatives without a diagnosis.
This can only be for one purpose that's not explicitly stated. Genetic counselling.
In theory couples in the future might seek genetic testing prior to having kids to see what the probability is of having an autistic kid. The next step would be some type of prenatal test like for Downs syndrome.
It would also open the prospect for gene testing for sperm and egg donors.
Not sure how this direction sits with the WP community and whether it has an impact on social stigma against autism and by extension the autistic community?
Well, the obvious goal is to prevent or hopefully treat all developmental disorders, illness & disability.
Many advocates will lament at this while conveniently forgetting that nature itself is great at negative Eugenics, it never cures just makes sure we stay disabled, unattractive & never reproduce. Many of us autistic men die middle age virgins after all and being autistic is hardly a catch to young women.
You touch upon genetic counselling but in the not-too-distant future (maybe within two decades?) we are inevitably likely to start seeing genetic matchmaking linked to dating sites, so young people will simply upload their genetic info and the dating site will pick the best matches & warn against genetic mismatches like disability in offspring, a kind of futuristic horoscope. It will be so natural that every new couple will likely do it especially women looking for a man to eventually have kids with.
Unfortunately, this is likely to create a genetic underclass.
In the UK they announced last year all new-borns will have full genome testing, COVID-19 emergency has delayed this a bit but it will eventually happen and knowing your own genome will be like knowing your blood group.
I support gene research if it reduces suffering and makes disabled people who want it more functional, there are probably many different types of autism & both opposite extremes don’t deserve to be on the same page.
They are already starting to trial genetic therapy for Angelman syndrome but didn’t get off to a good start, no doubt they will try again & the genetic mrna COVID vaccines has probably advanced genetic medicine massively, since its likely by the end of the year many of us will have taken a genetic form of medicine in the form of a vaccine.
This will likely kick start alot of other stuff not to mention the trillions that is likely to be invested in genetics to deal with a future COVID, that will also filter through to autism genetic reserach.
It’s inevitable and would rather us be helped by gene research than autistic people be cast off & forgotten about if its inevitably prevented, like the thalidomide victims were.
https://www.spectrumnews.org/news/gene- ... t-on-hold/
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"The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore all progress depends upon the unreasonable man."
- George Bernie Shaw
Yes, this is precisely what I think is the endgame.
Not sure if you have seen the Scifi movie "Gattaca" staring Ethan Hawke and Uma Thurman? it provides a fairly likely future where genetic profiling is commonplace and one's ability/capacity for social status, employment, finding a partner or having children is determined by your genetic profile.
Dating in the future will likely include a DNA profile.
I don't think its possible to stop this as it's inevitable.
I'm getting X-men sentinel mutant vibes. Dna databases. But yeah, this brave new world is inevitable, and for the time being are genes are somewhat useful in the silicon valley digital world, so im not sure they will be eliminated, maybe modified.
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AQ: 27 Diagnosis:High functioning (just on the cusp of normal.) IQ:131 (somewhat inflated result but ego-flattering) DNA:XY Location: UK. Eyes: Blue. Hair: Brown. Height:6'1 Celebrity I most resemble: Tom hardy. Favorite Band: The Doors. Personality: uhhm ....(what can i say...we asd people are strange)
There may be some NTs who (knowing the genetic risk) would still not mind having an Aspie partner despite higher than normal risk of having a child with autism? But having a child entering data in a Silicon valley company might not be enough to convince most NTs.
Wether we like it or not, aspie or normie, our data is being entered, logged, stored, recorded, regardless.
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AQ: 27 Diagnosis:High functioning (just on the cusp of normal.) IQ:131 (somewhat inflated result but ego-flattering) DNA:XY Location: UK. Eyes: Blue. Hair: Brown. Height:6'1 Celebrity I most resemble: Tom hardy. Favorite Band: The Doors. Personality: uhhm ....(what can i say...we asd people are strange)
CockneyRebel
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I think the data suggests that maybe 75-85% of women would opt for abortion https://www.theatlantic.com/health/arch ... on/273053/
But that still leaves 20-25% who would still have the child.
The issue with testing NTs is that many may choose not to have children at all if there is an elevated risk in their DNA profile.
CockneyRebel
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I think the current numbers run based on religious belief so those opting for keeping their children are likely to already have a stance against abortion.
Women should have the right to choose but its sad when mothers choose to terminate their disabled child.
I'm not sure it will come to that.
My understanding is that many of the more severe types of autism are related to de novo mutations which are not going to be picked up in looking at the familial genetics.
It is often the milder Asperger-type autism that can be seen to run in families.
So hopefully society will have come to a better understanding of the need for neurodiversity within the population before we get to a situation of autistic eugenics.
If genetic engineering is used for good then it could potentially offer real equality between people, not the fake identity politics one based on keeping people down & reliant on others in our senior hierarchy to negotiate for a few crumbs on our behalf.
Don`t we all deserve to be as smart as the smartest people
Don`t we all deserve to have the best communication skills of the best NT communicators
Why should we all suffer from social anxiety
Why should we suffer sensory problems
Why should many of us be condemned to a lower life span, poor job prospects & poverty because we cant work
Why shouldnt we all be allowed to form sucessful relationships with others like NT`s
_________________
"The reasonable man adapts himself to the world; the unreasonable one persists in trying to adapt the world to himself. Therefore all progress depends upon the unreasonable man."
- George Bernie Shaw
It is often the milder Asperger-type autism that can be seen to run in families. .
This makes sense that milder forms continue to run in families because people born with more severe forms of autism are unlikely to have children. It sounds like mendelian inheritance where if you allow the genes to concentrate enough (critical mass) after a few generations then the probability of severe autism increases.
I think there's an environmental factor too.
Stress and toxins leading to epigenetic changes in the sperm or ova before conception, that sort of thing.
So that a lot of the more severe autism cases appear to come "out of the blue" in families with no history.
I think there's still a lot of work to be done on understanding the epigenetics of autism. Toxins/triggers have not been readily identified to date because we need to look at transgenerational effects - exposure of the father (in the case of sperm) or the grandmother on the mother's side during pregnancy (in the case of ova).
Some are still hung up on theories about exposure of the autistic individual (eg the debunked vaccine link).
Last edited by MrsPeel on 10 Jan 2021, 10:53 pm, edited 1 time in total.
Don`t we all deserve to be as smart as the smartest people
Don`t we all deserve to have the best communication skills of the best NT communicators
Why should we all suffer from social anxiety
Why should we suffer sensory problems
Why should many of us be condemned to a lower life span, poor job prospects & poverty because we cant work
Why shouldnt we all be allowed to form sucessful relationships with others like NT`s
I'm not sure about this, the idea of trying to improve the human race so that we all get the best that we deserve doesn't sit right with me, as ideal as it sounds on the surface. Over and over again when we try to do that kind of thing we find unintended negative consequences. Usually it turns out that nature knows better than we do.
There is a good reason why some people are prone to anxiety, for example, just as there is a good reason why some people have narcissistic traits and others autistic traits. The natural diversity of humanity has arisen out of a powerful evolutionary process and we mess with that at our peril.
